公开(公告)号：EP3548500A1

公开(公告)日：2019-10-09

申请号：EP17797657.8

申请日：2017-11-15

申请人： Springtide Ventures s.r.o. ,  Smart Brain S.r.o. ,  Biotechnologicky Ustav AV CR, v.v.i. ,  Mitotax S.r.o.

发明人： HUBACKOVA, Sona ,  WERNER, Lukas ,  STURSA, Jan ,  NEUZIL, Jiri

IPC分类号： C07F9/54 ,  A61K31/662

摘要： The present invention relates to compounds of general formula I in particular for use in the treatment of senescence-related diseases, such as idiopathic pulmonary fibrosis, sarcopenia, diabetes, obesity, osteoarthritis, chronic inflammations, glaucoma, cataracts, radiation-induced oral mucosis, renal transplantation, prostatic hyperplasia.

公开(公告)号：EP4050025A1

公开(公告)日：2022-08-31

申请号：EP21159446.0

申请日：2021-02-26

申请人： Biotechnologicky ustav AV CR, v.v.i. ,  Univerzita Palackého v Olomouci

发明人： Maly, Petr ,  Raska, Milan ,  Kuchar, Milan ,  Kosztyu, Petr ,  Cerny, Jiri ,  Daniel Liskova, Veronika ,  Petrokova, Hana

IPC分类号： C07K14/47 ,  C07K16/10

摘要： The present invention provides polypeptides having a length of up to 180 amino acids and containing a sequence selected from sequences identical or differing at most in 5 amino acids from the sequence:

wherein
X 21 X 22 X 23 X 24 is selected from KAQQ, LSVF, ATPS, EIMW, DGSS, LLPL, WMWW, MNLY, MWRN, IMME, KHQL, HWQF, YAGN and HGQW;
X 50 X 51 X 52 is selected from RNT, IMF, GHE, PSW, RAN, YFW, ITL, QAM, DMR, WLW, QGE, VQY and VSL;
X 76 X 77 X 78 X 79 X 80 is selected from SHHLG, FMLMM, VILIL, IVTPL, DFIIW, MWSE(deletion), LYYAW, MMIEY, WMTQT, PQLWL, EPIFL and QTATY;
and optionally further having an affinity tag attached to the N-terminus or to the C-terminus of the sequence. These polypeptides mimic HIV-1 Env glycoprotein epitopes and are useful in preparation of antibodies and vaccines.

公开(公告)号：EP3280722A1

公开(公告)日：2018-02-14

申请号：EP16721001.2

申请日：2016-04-08

申请人： Ustav organicke chemie a biochemie AV CR, v.v.i. ,  Biotechnologicky Ustav AV CR, v.v.i.

发明人： CEROVSKY, Vaclav ,  NESUTA, Ondrej ,  DUDKOVA, Vlasta ,  SYCHROVA, Hana ,  KODEDOVA, Marie

IPC分类号： C07K7/08 ,  A61K38/04

CPC分类号： C07K7/08 ,  A61K38/00 ,  A61K38/04 ,  A61K38/10

摘要： Synthetic analogs of general formula (I-A), 5 a-Ile-b-c-d-e-f-Lys-Lys-g-h-i-j-Ile-k-Lys-NH2 (I-A) where a is Gly, Lys or β-Ala; b is Met, Leu, Nle, Ile, Trp, Val or Phe; c is Ser, Lys, Arg or Orn; d is Ser, Lys, Arg or Orn; e is Leu, Nle, Ile, Trp, Val or Phe; f is Met, Leu, Nle, Ile, Trp, Val or Phe; g is Leu, Nle, Ile orTrp; h is Lys, Arg, Orn or Ala; i is Lys, Arg, Orn or Ala; j is Ile, Leu, Nle or His; k is Lys, Arg, Orn or Ala; where amino acids in all positions may be in D-configuration, and their use for the treatment of topical infections caused by pathogenic bacteria or yeasts.

公开(公告)号：EP4090971A1

公开(公告)日：2022-11-23

申请号：EP21703812.4

申请日：2021-01-17

申请人： Biotechnologicky ustav AV CR, v.v.i. ,  Primecell Bioscience A.S. ,  Ceská zemedelská univerzita v Praze

发明人： KOMRSKOVA, Katerina ,  POSTLEROVA, Pavla ,  FROLIKOVA, Michaela ,  FOROSTYAK, Serhiy ,  SIMONIK, Ondrej

IPC分类号： G01N33/50 ,  G01N33/68

公开(公告)号：EP3851852A1

公开(公告)日：2021-07-21

申请号：EP20152470.9

申请日：2020-01-17

申请人： Biotechnologicky Ustav AV CR, v.v.i. ,  PrimeCell Advanced Therapy, a.s. ,  Ceská zemedelská univerzita v Praze

发明人： Komrskova, Katerina ,  Postlerova, Pavla ,  Frolikova, Michaela ,  Zahradnicek, Michal ,  Pospisilova, Veronika ,  Forostyak, Serhiy ,  Simonik, Ondrej

IPC分类号： G01N33/50 ,  G01N33/68

摘要： The present invention provides a method of separation of sperm cells with undamaged intact heads from sperm cells with damaged heads and/or somatic cells and/or cell debris in a cell sample obtained from an animal, comprising the steps of:
- providing an anti-CD46 antibody bound to a carrier and/or to a tag;
- contacting the cell sample with the anti-CD46 antibody bound to the carrier and/or to the tag in order to bind CD46 presenting cells and/or cell debris from the cell sample to the anti-CD46 antibody;
- removing the CD46 presenting cells bound via the anti-CD46 antibody to the carrier and/or to the tag to obtain a cell sample free of CD46 presenting cells, wherein CD46 presenting cells include sperm cells with damaged heads, somatic cells and cell debris.
This technology is designed to separate sperm with undamaged intact heads to be further used in assisted reproduction, medicine (in particular breeding programs and veterinary medicine), storage purpose, and research.

公开(公告)号：EP3442594A1

公开(公告)日：2019-02-20

申请号：EP17721952.4

申请日：2017-04-10

申请人： Ustav Makromolekularni Chemie AV CR, v.v.i. ,  Biotechnologicky Ustav AV CR, v.v.i.

发明人： ETRYCH, Tomas ,  KOSTKA, Libor ,  BRAUNOVA, Alena ,  CUCHALOVA, Lucie ,  SIROVA, Milada ,  JANOUSKOVA, Olga

IPC分类号： A61K47/60 ,  A61K47/58 ,  A61K47/65 ,  A61K47/69 ,  A61K9/107 ,  A61P35/00 ,  A61P35/02

公开(公告)号：EP2922560A1

公开(公告)日：2015-09-30

申请号：EP13792577.2

申请日：2013-10-25

申请人： Biotechnologicky Ustav AV CR, v.v.i.

发明人： MALY, Petr ,  SEBO, Peter ,  KUCHAR, Milan ,  VANKOVA, Lucie ,  PETROKOVA, Hana ,  OSICKA, Radim

IPC分类号： A61K38/17 ,  C07K16/28 ,  C07K14/315

CPC分类号： C07K14/7155 ,  A61K38/1793 ,  C07K16/2866 ,  C07K2317/76 ,  C07K2318/20

摘要： The present invention provides a novel class of polypeptides (REX binders), derived from an albumin-binding domain of the streptococcal protein G that inhibit binding of human IL-23 cytokine to its cognate IL-23 receptor. Blocking of interaction between p19/IL-23 subunit with the receptor leads to the suppresion of IL-23-dependent pro-inflammatory signaling pathway, resulting in an inhibitory effect on IL-23-stimulated Th-17 cell expansion. The invention further provides a DNA sequence encoding for such polypeptides and host cells containing such sequence. The polypeptides of the invention are useful as therapeutics and diagnostics.˙

摘要翻译： 本发明提供衍生自链球菌蛋白G的白蛋白结合结构域的新型多肽（REX结合物），其抑制人IL-23细胞因子与其同源IL-23受体的结合。 阻断p19 / IL-23亚基与受体之间的相互作用导致抑制IL-23依赖性促炎症信号通路，导致对IL-23刺激的Th-17细胞扩增的抑制作用。 本发明还提供编码这种多肽的DNA序列和含有该序列的宿主细胞。 本发明的多肽可用作治疗和诊断

公开(公告)号：EP4090972A1

公开(公告)日：2022-11-23

申请号：EP21703813.2

申请日：2021-01-17

申请人： Biotechnologicky ustav AV CR, v.v.i. ,  Primecell Bioscience A.S. ,  Ceská zemedelská univerzita v Praze

发明人： KOMRSKOVA, Katerina ,  POSTLEROVA, Pavla ,  FROLIKOVA, Michaela ,  FOROSTYAK, Serhiy ,  SIMONIK, Ondrej

IPC分类号： G01N33/50 ,  C07K16/28 ,  C12N5/071

公开(公告)号：EP3851853A1

公开(公告)日：2021-07-21

申请号：EP20152484.0

申请日：2020-01-17

申请人： Biotechnologicky Ustav AV CR, v.v.i. ,  PrimeCell Advanced Therapy, a.s. ,  Ceská zemedelská univerzita v Praze

发明人： Komrskova, Katerina ,  Postlerova, Pavla ,  Frolikova, Michaela ,  Zahradnicek, Michal ,  Pospisilova, Veronika ,  Forostyak, Serhiy ,  Simonik, Ondrej

IPC分类号： G01N33/50 ,  C12N5/076

摘要： The present invention provides a method of separation of sperm cells with undamaged intact heads from sperm cells with damaged heads and/or somatic cells and/or cell debris in a cell sample obtained from a human, comprising the steps of:
- providing an anti-CD46 antibody bound to a carrier and/or to a tag;
- contacting the cell sample with the anti-CD46 antibody bound to the carrier and/or to the tag in order to bind CD46 presenting cells and/or cell debris from the cell sample to the anti-CD46 antibody;
- removing the CD46 presenting cells bound via the anti-CD46 antibody to the carrier and/or to the tag to obtain a cell sample free of CD46 presenting cells, wherein CD46 presenting cells include sperm cells with damaged heads, somatic cells and cell debris.
The technology of the invention is in particular designed to separate sperm with undamaged intact heads to be further used in assisted reproduction, human medicine and research.

公开(公告)号：EP3655414A1

公开(公告)日：2020-05-27

申请号：EP18742393.4

申请日：2018-07-13

申请人： Biotechnologicky Ustav AV CR, V.V.I. ,  Smart Brain S.r.o.

发明人： TRUKSA, Jaroslav ,  WERNER, Lukas ,  STURSA, Jan

IPC分类号： C07F9/54 ,  A61K31/66 ,  A61P35/00