发明公开
- 专利标题： ARCHAEAL PYRROLYSYL TRNA SYNTHETASES FOR ORTHOGONAL USE
- 专利标题（中）： 用于正交使用的原虫聚吡咯酰化合物
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申请号： EP16194038.2申请日： 2016-10-14
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公开(公告)号： EP3309260A1公开(公告)日： 2018-04-18
- 发明人: LEMKE, Edward , NIKIC, Ivana , ESTRADA GIRONA, Gemma , KÖHLER, Christine
- 申请人： European Molecular Biology Laboratory
- 申请人地址： Meyerhofstrasse 1 69117 Heidelberg DE
- 专利权人： European Molecular Biology Laboratory
- 当前专利权人： European Molecular Biology Laboratory
- 当前专利权人地址： Meyerhofstrasse 1 69117 Heidelberg DE
- 代理机构： Reitstötter Kinzebach
- 主分类号： C12P21/02
- IPC分类号： C12P21/02 ; C12N15/11
摘要：
The invention relates to archaeal pyrrolysyl tRNA synthetases lacking a nuclear localization signal and/or comprising a nuclear export signal. The invention also relates to polynucleotides encoding said pyrrolysyl tRNA synthetases, eukaryotic cells comprising said polynucleotide and tRNA acylated by the pyrrolysyl tRNA synthetase or a polynucleotide encoding such tRNA, methods utilizing said cells for preparing polypeptides comprising unnatural amino acid residues, and kits useful in said methods.
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