- 专利标题： DELIVERY OF THERAPEUTIC AGENTS BY A COLLAGEN BINDING PROTEIN
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申请号： EP18173596.0申请日： 2012-12-14
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公开(公告)号： EP3391899A1公开(公告)日： 2018-10-24
- 发明人: Sakon, Joshua , Philominathan, Sagaya, Theresa, Leena , Katikaneni, Ranjitha , Matsushita, Osamu , Ponnapakkam, Tulasi , Koide, Takaki , Gensure, Robert, C. , Nishi, Nozomu
- 申请人： The Board of Trustees of the University of Arkansas , The Kitasato Institute , Montefiore Medical Center , National University Corporation Kagawa University
- 申请人地址： 2404 North University Avenue Little Rock, AR 72207 US
- 专利权人： The Board of Trustees of the University of Arkansas,The Kitasato Institute,Montefiore Medical Center,National University Corporation Kagawa University
- 当前专利权人： The Board of Trustees of the University of Arkansas,The Kitasato Institute,Montefiore Medical Center,National University Corporation Kagawa University
- 当前专利权人地址： 2404 North University Avenue Little Rock, AR 72207 US
- 代理机构： Ward, Eliot Michael
- 优先权： US201161570620P 20111214; US201261596869P 20120209
- 主分类号： A61K38/16
- IPC分类号： A61K38/16
摘要：
Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. In these methods, the therapeutic agent is not a PTH/PTHrP receptor agonist or antagonist, basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). The bacterial collagen-binding polypeptide segment delivers the agent to sites of partially untwisted or under-twisted collagen. Methods of treating collagenopathies using a composition including a collagen-binding polypeptide and a PTH/PTHrP receptor agonist are also provided. In addition, methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. Finally, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.
公开/授权文献
- EP3391899B1 DELIVERY OF THERAPEUTIC AGENTS BY A COLLAGEN BINDING PROTEIN 公开/授权日：2020-07-15
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