公开(公告)号：EP3391899B1

公开(公告)日：2020-07-15

申请号：EP18173596.0

申请日：2012-12-14

申请人： The Board of Trustees of the University of Arkansas ,  The Kitasato Institute ,  Montefiore Medical Center ,  National University Corporation Kagawa University

发明人： Sakon, Joshua ,  Philominathan, Sagaya, Theresa, Leena ,  Katikaneni, Ranjitha ,  Matsushita, Osamu ,  Ponnapakkam, Tulasi ,  Koide, Takaki ,  Gensure, Robert, C. ,  Nishi, Nozomu

IPC分类号： A61K38/16

公开(公告)号：EP3391899A1

公开(公告)日：2018-10-24

申请号：EP18173596.0

申请日：2012-12-14

申请人： The Board of Trustees of the University of Arkansas ,  The Kitasato Institute ,  Montefiore Medical Center ,  National University Corporation Kagawa University

发明人： Sakon, Joshua ,  Philominathan, Sagaya, Theresa, Leena ,  Katikaneni, Ranjitha ,  Matsushita, Osamu ,  Ponnapakkam, Tulasi ,  Koide, Takaki ,  Gensure, Robert, C. ,  Nishi, Nozomu

IPC分类号： A61K38/16

摘要： Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. In these methods, the therapeutic agent is not a PTH/PTHrP receptor agonist or antagonist, basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). The bacterial collagen-binding polypeptide segment delivers the agent to sites of partially untwisted or under-twisted collagen. Methods of treating collagenopathies using a composition including a collagen-binding polypeptide and a PTH/PTHrP receptor agonist are also provided. In addition, methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. Finally, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.