摘要:
L'invention peut être utilisée afin d'obtenir des images à trois dimensions de tout objet devant être visualisé ou mesuré, y compris le corps humain. Les images à trois dimensions peuvent être utilisées afin de produire des visualisations bidimensionnelles ou à perspective à trois dimensions. Cette caractéristique facilite le calcul de la superficie ou du volume de l'objet. Un sous-système imageur ultrasonore (21, 22) produit des signaux qui représentent les images des sections de l'objet. Les signaux d'images sont stockés en tant que matrices de valeurs de pixels numériques (117). On prévoit des moyens (110) servant à dériver et à stocker des informations qui représentent la position et l'orientation du transducteur pendant l'analyse d'une section associée de l'objet. Les matrices des valeurs de pixels sont ensuite introduites dans des emplacements de mémoire de voxels.
摘要:
The present invention relates to a method for determining the state of disease progression thereby providing a means for the detection of said disease and in the risk evaluation for the development of said disease. In particular, the present invention contemplates a method for determining and monitoring the state of malignant or premalignant progression or risk of development of malignant or premalignant progression in mammalian tissue or cells. In particular, the present invention is directed to benign and malignant colon tumors and benignly and malignantly transformed colon cells. The present invention is predicated on the discovery that the abundance of specific first nucleic acids changes in response to the disease state. The present invention is also directed to recombinant second nucleic acids useful in the detection and quantification of the first nucleic acids by hybridization. The present invention also contemplates the use of polypeptides encoded by said second nucleic acids in the regression and prophylaxis of disease states.
摘要:
Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. In these methods, the therapeutic agent is not a PTH/PTHrP receptor agonist or antagonist, basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). The bacterial collagen-binding polypeptide segment delivers the agent to sites of partially untwisted or under-twisted collagen. Methods of treating collagenopathies using a composition including a collagen-binding polypeptide and a PTH/PTHrP receptor agonist are also provided. In addition, methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. Finally, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.
摘要:
Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. In these methods, the therapeutic agent is not a PTH/PTHrP receptor agonist or antagonist, basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). The bacterial collagen-binding polypeptide segment delivers the agent to sites of partially untwisted or under-twisted collagen. Methods of treating collagenopathies using a composition including a collagen-binding polypeptide and a PTH/PTHrP receptor agonist are also provided. In addition, methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. Finally, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.