- 专利标题： SOLUBLE CD52 FOR USE IN THE TREATMENT OR PREVENTION OF MULTIPLE SCLEROSIS OR RHEUMATOID ARTHRITIS
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申请号： EP18193427.4申请日： 2012-11-15
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公开(公告)号： EP3456338A1公开(公告)日： 2019-03-20
- 发明人: BANDALA SANCHEZ, Esther , DROMEY, James , HARRISON, Leonard Charles , ZHANG, Yuxia
- 申请人： The Walter and Eliza Hall Institute of Medical Research
- 申请人地址： Wehi 1G Royal Parade Parkville Melbourne, VIC 3052 AU
- 专利权人： The Walter and Eliza Hall Institute of Medical Research
- 当前专利权人： The Walter and Eliza Hall Institute of Medical Research
- 当前专利权人地址： Wehi 1G Royal Parade Parkville Melbourne, VIC 3052 AU
- 代理机构： Sweetinburgh, Mark Roger
- 优先权： US201161560254P 20111115; US201261705633P 20120926
- 主分类号： A61K38/10
- IPC分类号： A61K38/10 ; A61K38/28 ; C12N15/12 ; C12N15/86 ; G01N33/15 ; A61P5/50 ; A61P37/06
摘要：
The present disclosure relates to a soluble CD52 glycoprotein and its use in treating diseases regulated by effector T-cells, for example autoimmune diseases such as type 1 diabetes. The present disclosure also relates to fusion proteins comprising the soluble glycoprotein, to cells expressing high levels of CD52, and to diagnostic methods based on the detection of CD52 expression levels in a subject.
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