公开(公告)号：EP3456338B1

公开(公告)日：2020-07-29

申请号：EP18193427.4

申请日：2012-11-15

申请人： The Walter and Eliza Hall Institute of Medical Research

发明人： BANDALA SANCHEZ, Esther ,  DROMEY, James ,  HARRISON, Leonard Charles ,  ZHANG, Yuxia

IPC分类号： A61K38/10 ,  A61K38/28 ,  C12N15/12 ,  C12N15/86 ,  G01N33/15 ,  A61P5/50 ,  A61P37/06

公开(公告)号：EP3456338A1

公开(公告)日：2019-03-20

申请号：EP18193427.4

申请日：2012-11-15

申请人： The Walter and Eliza Hall Institute of Medical Research

发明人： BANDALA SANCHEZ, Esther ,  DROMEY, James ,  HARRISON, Leonard Charles ,  ZHANG, Yuxia

IPC分类号： A61K38/10 ,  A61K38/28 ,  C12N15/12 ,  C12N15/86 ,  G01N33/15 ,  A61P5/50 ,  A61P37/06

摘要： The present disclosure relates to a soluble CD52 glycoprotein and its use in treating diseases regulated by effector T-cells, for example autoimmune diseases such as type 1 diabetes. The present disclosure also relates to fusion proteins comprising the soluble glycoprotein, to cells expressing high levels of CD52, and to diagnostic methods based on the detection of CD52 expression levels in a subject.

公开(公告)号：EP2919799A1

公开(公告)日：2015-09-23

申请号：EP13855431.6

申请日：2013-03-25

申请人： The Walter and Eliza Hall Institute of Medical Research

发明人： HARRISON, Leonard Charles ,  RASHIDI, Maryam ,  ZHANG, Yuxia

IPC分类号： A61K38/10 ,  C12N15/12 ,  C12N15/86 ,  G01N33/15 ,  G01N33/50 ,  A61P37/06

CPC分类号： G01N33/6896 ,  A61K38/00 ,  C07K14/70592 ,  C07K16/2803 ,  C07K16/2863 ,  C07K16/2866 ,  C07K16/2893 ,  C07K2317/76 ,  C07K2319/30 ,  C12N5/0637 ,  G01N33/502 ,  G01N33/564 ,  G01N33/6872 ,  G01N33/6893 ,  G01N2333/70592 ,  G01N2800/26 ,  G01N2800/285 ,  G01N2800/50 ,  G01N2800/52

摘要： The present disclosure relates to the use of a soluble CD52 glycoprotein in treating diseases regulated by effector T-cells, for example sepsis or multiple sclerosis. The present disclosure also relates to diagnostic methods based on the detection of CD52 expression levels in a subject.

摘要翻译： 本公开涉及可溶性CD52糖蛋白在治疗由效应T细胞调节的疾病中的用途，所述疾病例如脓毒症或多发性硬化症。 本公开还涉及基于检测受试者中的CD52表达水平的诊断方法。

公开(公告)号：EP2750690A1

公开(公告)日：2014-07-09

申请号：EP12850386.9

申请日：2012-11-15

申请人： The Walter and Eliza Hall Institute of Medical Research

发明人： BANDALA SANCHEZ, Esther ,  DROMEY, James ,  HARRISON, Leonard Charles ,  ZHANG, Yuxia ,  RASHIDI, Maryam

IPC分类号： A61K38/10 ,  A61K38/28 ,  C12N15/12 ,  C12N15/86 ,  G01N33/15 ,  A61P5/50 ,  A61P37/06

CPC分类号： A61K38/177 ,  A61K38/10 ,  A61K47/68 ,  A61K48/00 ,  C07K14/70592 ,  C07K16/18 ,  C07K2319/30 ,  C12N5/0637 ,  C12Q1/6883 ,  G01N33/505 ,  G01N33/6872

摘要： The present disclosure relates to a soluble CD52 glycoprotein and its use in treating diseases regulated by effector T-cells, for example autoimmune diseases such as type 1 diabetes. The present disclosure also relates to fusion proteins comprising the soluble glycoprotein, to cells expressing high levels of CD52, and to diagnostic methods based on the detection of CD52 expression levels in a subject.

摘要翻译： 本公开涉及可溶性CD52糖蛋白及其在治疗由效应T细胞调节的疾病中的应用，所述疾病例如自身免疫疾病如1型糖尿病。 本公开还涉及包含可溶性糖蛋白，表达高水平CD52的细胞的融合蛋白，以及基于检测受试者中CD52表达水平的诊断方法。