- 专利标题： PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER
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申请号： EP18197155.7申请日： 2011-06-03
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公开(公告)号： EP3483143A8公开(公告)日： 2020-04-15
- 发明人: Bartberger, Michael David , Gonzalez Buenrostro, Ana , Beck, Hilary Place , Chen, Xiaoqi , Connors, Richard Victor , Deignan, Jeffrey , Duquette, Jason A. , Eksterowicz, John , Fisher, Benjamin , Fox, Brian Matthew , Fu, Jiasheng , Fu, Zice , Gonzalez Lopez de Turiso, Felix , Gribble, Jr., Michael William , Gustin, Darin James , Heath, Julie Anne , Huang, Xin , Jiao, Xianjun , Johnson, Michael , Kayser, Frank , Kopecky, David John , Lai, Sujen , Li, Yihong , Li, Zhihong , Liu, Jiwen , Low, Jonathan Dante , Lucas, Brian Stuart , Ma, Zhihua , McGee, Lawrence R. , McIntosh, Joel , McMinn, Dustin , Medina, Julio Cesar , Mihalic, Jeffrey Thomas , Olson, Steven Howard , Rew, Yosup , Roveto, Philip Marley , Sun, Daqing , Wang, Xiaodong , Wang, Yingcai , Yan, Xuelei , Yu, Ming , Zhu, Jiang
- 申请人： Amgen Inc.
- 申请人地址： One Amgen Center Drive Thousand Oaks, California 91320-1799 US
- 专利权人： Amgen Inc.
- 当前专利权人： Amgen Inc.
- 当前专利权人地址： One Amgen Center Drive Thousand Oaks, California 91320-1799 US
- 代理机构： Hoffmann Eitle
- 优先权： US35182710P 20100604; US35232210P 20100607; US201161452578P 20110314
- 主分类号： C07D211/40
- IPC分类号： C07D211/40 ; C07D401/04 ; C07D401/06 ; C07D407/04 ; C07D407/06 ; C07D409/04 ; C07D413/06 ; C07D417/06 ; C07D471/20 ; C07D279/02 ; C07D401/12 ; C07D498/08 ; C07D498/20 ; A61K31/4412 ; A61P35/00
摘要：
The present invention provides MDM2 inhibitor compounds of Formula IE,
which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.
which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.
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