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公开(公告)号：EP2927213B1
公开(公告)日：2018-11-14
申请号：EP15159363.9
申请日：2011-06-03
申请人： Amgen Inc.
发明人： Bartberger, Michael David , Gonzalez Buenrostro, Ana , Beck, Hilary Plake , Chen, Xiaoqi , Connors, Richard Victor , Deignan, Jeffery , Duquette, Jason , Eksterowicz, John , Fisher, Benjamin , Fox, Brian Matthew , Fu, Jiasheng , Fu, Zice , Gonzalez Lopez de Turiso, Felix , Gribble, jr. Michael William , Gustin, Darin James , Heath, Julie Anne , Huang, Xin , Jiao, Xianjun , Johnson, Michael , Kayser, Frank , Kopecky, David John , Lai, SuJen , Li, Yihong , Li, Zhihong , Liu, Jiwen , Low, Jonathan Dante , Lucas, Brian Stuart , Ma, Zhihua , McGee, Lawrence , McIntosh, Joel , McMinn, Dustin , Medina, Julio Cesar , Mihalic, Jeffrey Thomas , Olson, Steven Howard , Rew, Yosup , Roveto, Philip Marley , Sun, Daqing , Wang, Xiaodong , Wang, Yingcai , Yan, Xuelei , Yu, Ming , Zhu, Jiang
IPC分类号： C07D211/40 , C07D401/04 , C07D401/06 , C07D407/04 , C07D407/06 , C07D409/04 , C07D413/06 , C07D417/06 , C07D471/20 , C07D279/02 , C07D401/12 , C07D498/08 , C07D498/20 , A61K31/4412 , A61P35/00
CPC分类号： C07D211/76 , C07D221/20 , C07D279/02 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/12 , C07D407/04 , C07D407/06 , C07D409/04 , C07D409/12 , C07D413/06 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/10 , C07D491/08 , C07D491/153 , C07D498/08 , C07D498/14 , C07D498/20
摘要： The present invention provides MDM2 inhibitor compounds of Formula IE, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.
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2.发明公开
公开(公告)号：EP2760845A1
公开(公告)日：2014-08-06
申请号：EP12775888.6
申请日：2012-09-26
申请人： Amgen Inc.
发明人： Bartberger, Michael D. , Beck, Hilary Plake , Chen, Xiaoqi , Connors, Richard V. , Deignan, Jeffrey , Duquette, Jason A. , Eksterowicz, John , Fox, Brian M. , Fu, Jiasheng , Gonzalez Buenrostro, Ana , Gonzalez Lopez de Turiso, Felix , Gustin, Darin J. , Heath, Julie A. , Johnson, Michael G. , Kayser, Frank , Kopecky, David J. , Li, Yihong , Li, Zhihong , Ma, Zhihua , McIntosh, Joel , Medina, Julio C. , Mihalic, Jeffrey T. , Olson, Steven H. , Rew, Yosup , Roveto, Philip M. , Schmitt, Michael J. , Sun, Daqing , Wang, Xiaodong , Wanska, Malgorzata , Weathers, Christine , Yan, Xuelei
IPC分类号： C07D265/06 , C07D413/04 , C07D413/10 , C07D417/04 , C07D413/12
CPC分类号： C07D413/04 , C07D265/06 , C07D265/32 , C07D413/10 , C07D413/12 , C07D417/04
摘要： The present invention provides MDM2 inhibitor compounds of Formula I or II, or the pharmaceutically acceptable salts thereof, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.
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3.发明授权
公开(公告)号：EP2760845B1
公开(公告)日：2016-11-16
申请号：EP12775888.6
申请日：2012-09-26
申请人： Amgen Inc.
发明人： Bartberger, Michael D. , Beck, Hilary Plake , Chen, Xiaoqi , Connors, Richard V. , Deignan, Jeffrey , Duquette, Jason A. , Eksterowicz, John , Fox, Brian M. , Fu, Jiasheng , Gonzalez Buenrostro, Ana , Gonzalez Lopez de Turiso, Felix , Gustin, Darin J. , Heath, Julie A. , Johnson, Michael G. , Kayser, Frank , Kopecky, David J. , Li, Yihong , Li, Zhihong , Ma, Zhihua , McIntosh, Joel , Medina, Julio C. , Mihalic, Jeffrey T. , Olson, Steven H. , Rew, Yosup , Roveto, Philip M. , Schmitt, Michael J. , Sun, Daqing , Wang, Xiaodong , Wanska, Malgorzata , Weathers, Christine , Yan, Xuelei
IPC分类号： C07D265/06 , C07D413/04 , C07D413/10 , C07D417/04 , C07D413/12
CPC分类号： C07D413/04 , C07D265/06 , C07D265/32 , C07D413/10 , C07D413/12 , C07D417/04
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4.发明公开Piperidinone derivatives as MDM2 inhibitors for the treatment of cancer 审中-公开Piperidinonderivate als MDM2-Hemmer zur Krebsbehandlung
公开(公告)号：EP2927213A1
公开(公告)日：2015-10-07
申请号：EP15159363.9
申请日：2011-06-03
申请人： Amgen Inc.
发明人： Bartberger, Michael David , Gonzalez Buenrostro, Ana , Beck, Hilary Plake , Chen, Xiaoqi , Connors, Richard Victor , Deignan, Jeffery , Duquette, Jason , Eksterowicz, John , Fisher, Benjamin , Fox, Brian Matthew , Fu, Jiasheng , Fu, Zice , Gonzalez Lopez de Turisco, Felix , Gribble, jr. Michael William , Gustin, Darin James , Heath, Julie Anne , Huang, Xin , Jiao, Xianjun , Johnson, Michael , Kayser, Frank , Kopecky, David John , Lai, Sujen , Li, Yihong , Li, Zhihong , Liu, Jiwen , Low, Jonathan Dante , Lucas, Brian Stuart , Ma, Zhihua , McGee, Lawrence , McIntosh, Joel , McMinn, Dustin , Medina, Julio Cesar , Mihalic, Jeffrey Thomas , Olson, Steven Howard , Rew, Yosup , Roveto, Philip Marley , Sun, Daqing , Wang, Xiaodong , Wang, Yingcai , Yan, Xuelei , Yu, Ming , Zhu, Jiang
IPC分类号： C07D211/40 , C07D401/04 , C07D401/06 , C07D407/04 , C07D407/06 , C07D409/04 , C07D413/06 , C07D417/06 , C07D471/20 , C07D279/02 , C07D401/12 , C07D498/08 , C07D498/20 , A61K31/4412 , A61P35/00
CPC分类号： C07D211/76 , C07D221/20 , C07D279/02 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/12 , C07D407/04 , C07D407/06 , C07D409/04 , C07D409/12 , C07D413/06 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/10 , C07D491/08 , C07D491/153 , C07D498/08 , C07D498/14 , C07D498/20
摘要： The present invention provides MDM2 inhibitor compounds of Formula IE,
which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.摘要翻译： 本发明提供式IE的MDM2抑制剂化合物，该化合物可用作治疗剂，特别是用于治疗癌症。 本发明还涉及含有MDM2抑制剂的药物组合物。
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公开(公告)号：EP3483143A8
公开(公告)日：2020-04-15
申请号：EP18197155.7
申请日：2011-06-03
申请人： Amgen Inc.
发明人： Bartberger, Michael David , Gonzalez Buenrostro, Ana , Beck, Hilary Place , Chen, Xiaoqi , Connors, Richard Victor , Deignan, Jeffrey , Duquette, Jason A. , Eksterowicz, John , Fisher, Benjamin , Fox, Brian Matthew , Fu, Jiasheng , Fu, Zice , Gonzalez Lopez de Turiso, Felix , Gribble, Jr., Michael William , Gustin, Darin James , Heath, Julie Anne , Huang, Xin , Jiao, Xianjun , Johnson, Michael , Kayser, Frank , Kopecky, David John , Lai, Sujen , Li, Yihong , Li, Zhihong , Liu, Jiwen , Low, Jonathan Dante , Lucas, Brian Stuart , Ma, Zhihua , McGee, Lawrence R. , McIntosh, Joel , McMinn, Dustin , Medina, Julio Cesar , Mihalic, Jeffrey Thomas , Olson, Steven Howard , Rew, Yosup , Roveto, Philip Marley , Sun, Daqing , Wang, Xiaodong , Wang, Yingcai , Yan, Xuelei , Yu, Ming , Zhu, Jiang
IPC分类号： C07D211/40 , C07D401/04 , C07D401/06 , C07D407/04 , C07D407/06 , C07D409/04 , C07D413/06 , C07D417/06 , C07D471/20 , C07D279/02 , C07D401/12 , C07D498/08 , C07D498/20 , A61K31/4412 , A61P35/00
摘要： The present invention provides MDM2 inhibitor compounds of Formula IE,
which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.-
公开(公告)号：EP3483143A1
公开(公告)日：2019-05-15
申请号：EP18197155.7
申请日：2011-06-03
申请人： Amgen, Inc
发明人： Bartberger, Michael David , Gonzalez Buenrostro, Ana , Beck, Hilary Place , Chen, Xiaoqi , Connors, Richard Victor , Deignan, Jeffrey , Duquette, Jason A. , Eksterowicz, John , Fisher, Benjamin , Fox, Brian Matthew , Fu, Jiasheng , Fu, Zice , Gonzalez Lopez de Turiso, Felix , Gribble, Jr., Michael William , Gustin, Darin James , Heath, Julie Anne , Huang, Xin , Jiao, Xianjun , Johnson, Michael , Kayser, Frank , Kopecky, David John , Lai, Sujen , Li, Yihong , Li, Zhihong , Liu, Jiwen , Low, Jonathan Dante , Lucas, Brian Stuart , Ma, Zhihua , McGee, Lawrence R. , McIntosh, Joel , McMinn, Dustin , Medina, Julio Cesar , Mihalic, Jeffrey Thomas , Olson, Steven Howard , Rew, Yosup , Roveto, Philip Marley , Sun, Daqing , Wang, Xiaodong , Wang, Yingcai , Yan, Xuelei , Yu, Ming , Zhu, Jiang
IPC分类号： C07D211/40 , C07D401/04 , C07D401/06 , C07D407/04 , C07D407/06 , C07D409/04 , C07D413/06 , C07D417/06 , C07D471/20 , C07D279/02 , C07D401/12 , C07D498/08 , C07D498/20 , A61K31/4412 , A61P35/00
摘要： The present invention provides MDM2 inhibitor compounds of Formula IE,
which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.
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