- 专利标题: POLYMORPHIC FORM OF KINASE INHIBITOR COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND PREPARATION METHOD THEREFOR AND USE THEREOF
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申请号: EP17855006.7申请日: 2017-09-29
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公开(公告)号: EP3502105A1公开(公告)日: 2019-06-26
- 发明人: LIANG, Congxin , XIE, Lihua
- 申请人: Betta Pharmaceuticals Co., Ltd. , Equinox Sciences, LLC.
- 申请人地址: 355 Xingzhong Rd. Yuhang Hangzhou Zhejiang 311100 CN
- 专利权人: Betta Pharmaceuticals Co., Ltd.,Equinox Sciences, LLC.
- 当前专利权人: Betta Pharmaceuticals Co., Ltd.,Equinox Sciences, LLC.
- 当前专利权人地址: 355 Xingzhong Rd. Yuhang Hangzhou Zhejiang 311100 CN
- 代理机构: Gille Hrabal
- 优先权: CN201610866253 20160929
- 国际公布: WO2018059556 20180405
- 主分类号: C07D403/14
- IPC分类号: C07D403/14 ; A61K31/404 ; A61P35/00
摘要:
The invention discloses polymorphic forms of a compound of formula I, pharmaceutical compositions containing same, preparation method therefor and use thereof. The compound of formula I of the present invention is as shown in formula I, of which the crystalline form can be crystalline form 1, crystalline form 2, crystalline form 3, crystalline form 5, crystalline form 6 or crystalline form 7. All the crystalline forms of the compound of formula I in the present invention have good crystalline stability and chemical stability and a decrease in purity of their main ingredient less than 2%. The preparation method of the present invention may be used to produce the various crystalline forms of the compound of formula I with high purity, and suitable for large scale production.
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