- 专利标题： ANTI-CTLA-4 ANTIBODIES AND METHODS OF USE THEREOF
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申请号： EP20168222.6申请日： 2016-05-27
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公开(公告)号： EP3736290A1公开(公告)日： 2020-11-11
- 发明人: Van DIJK, Marc , MUNDT, Cornelia Anne , RITTER, Gerd , SCHAER, David , WOLCHOK, Jedd David , MERGHOUB, Taha , SAVITSKY, David Adam , FINDEIS, Mark Arthur , WILSON, Nicholas S
- 申请人： Agenus Inc. , Memorial Sloan-Kettering Cancer Center , Ludwig Institute for Cancer Research Ltd.
- 申请人地址： 3 Forbes Road Lexington, MA 02421 US
- 专利权人： Agenus Inc.,Memorial Sloan-Kettering Cancer Center,Ludwig Institute for Cancer Research Ltd.
- 当前专利权人： Agenus Inc.,Memorial Sloan-Kettering Cancer Center,Ludwig Institute for Cancer Research Ltd.
- 当前专利权人地址： 3 Forbes Road Lexington, MA 02421 US
- 代理机构： Lahrtz, Fritz
- 优先权： US201562168391P 20150529; US201562182363P 20150619; US201562190653P 20150709; US201562257202P 20151118; US201662280263P 20160119; US201662292500P 20160208; US201662294558P 20160212; US201662323226P 20160415
- 主分类号： C07K16/28
- IPC分类号： C07K16/28
摘要：
The instant disclosure provides antibodies that specifically bind to human CTLA-4 and antagonize CTLA-4 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
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