公开(公告)号：EP4289484A3

公开(公告)日：2024-03-06

申请号：EP23190631.4

申请日：2017-12-07

申请人： Agenus Inc. ,  Ludwig Institute for Cancer Research Ltd. ,  Memorial Sloan-Kettering Cancer Center

发明人： VAN DIJK, Marc ,  MUNDT, Cornelia Anne ,  RITTER, Gerd ,  SCHAER, David ,  WOLCHOK, Jedd David ,  MERGHOUB, Taha ,  WILSON, Nicholas Stuart ,  SAVITSKY, David Adam ,  FINDEIS, Mark Arthur ,  UNDERWOOD, Dennis John ,  CUILLEROT, Jean-Marie ,  PROSCURSHIM, Igor ,  SHEBANOVA, Olga

IPC分类号： C07K16/28 ,  A61K39/00 ,  A61P11/00 ,  A61P35/04

摘要： The instant disclosure provides antibodies that specifically bind to CTLA-4 (e.g., human CTLA-4) and antagonize CTLA-4 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

公开(公告)号：EP4289484A2

公开(公告)日：2023-12-13

申请号：EP23190631.4

申请日：2017-12-07

申请人： Agenus Inc. ,  Ludwig Institute for Cancer Research Ltd. ,  Memorial Sloan-Kettering Cancer Center

发明人： VAN DIJK, Marc ,  MUNDT, Cornelia Anne ,  RITTER, Gerd ,  SCHAER, David ,  WOLCHOK, Jedd David ,  MERGHOUB, Taha ,  WILSON, Nicholas Stuart ,  SAVITSKY, David Adam ,  FINDEIS, Mark Arthur ,  UNDERWOOD, Dennis John ,  CUILLEROT, Jean-Marie ,  PROSCURSHIM, Igor ,  SHEBANOVA, Olga

IPC分类号： A61P35/04

摘要： The instant disclosure provides antibodies that specifically bind to CTLA-4 (e.g., human CTLA-4) and antagonize CTLA-4 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

公开(公告)号：EP3551225A1

公开(公告)日：2019-10-16

申请号：EP17818020.4

申请日：2017-12-07

申请人： Agenus Inc. ,  Ludwig Institute for Cancer Research Ltd ,  Memorial Sloan Kettering Cancer Center

发明人： VAN DIJK, Marc ,  MUNDT, Cornelia Anne ,  RITTER, Gerd ,  SCHAER, David ,  WOLCHOK, Jedd David ,  MERGHOUB, Taha ,  WILSON, Nicholas Stuart ,  SAVITSKY, David Adam ,  FINDEIS, Mark Arthur ,  ZAPPASODI, Roberta ,  HOLMGAARD, Rikke Bæk ,  CUILLEROT, Jean-Marie ,  PROSCURSHIM, Igor ,  SHEBANOVA, Olga

IPC分类号： A61K39/395 ,  C07K16/28

公开(公告)号：EP3736290A1

公开(公告)日：2020-11-11

申请号：EP20168222.6

申请日：2016-05-27

申请人： Agenus Inc. ,  Memorial Sloan-Kettering Cancer Center ,  Ludwig Institute for Cancer Research Ltd.

发明人： Van DIJK, Marc ,  MUNDT, Cornelia Anne ,  RITTER, Gerd ,  SCHAER, David ,  WOLCHOK, Jedd David ,  MERGHOUB, Taha ,  SAVITSKY, David Adam ,  FINDEIS, Mark Arthur ,  WILSON, Nicholas S

IPC分类号： C07K16/28

摘要： The instant disclosure provides antibodies that specifically bind to human CTLA-4 and antagonize CTLA-4 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

公开(公告)号：EP3526256A1

公开(公告)日：2019-08-21

申请号：EP17794131.7

申请日：2017-10-11

申请人： Agenus Inc.

发明人： WILSON, Nicholas Stuart ,  SAVITSKY, David Adam ,  JENNINGS, Shawn Michael ,  VAN DIJK, Marc ,  MUNDT, Cornelia Anne

IPC分类号： C07K16/28

公开(公告)号：EP3609921A2

公开(公告)日：2020-02-19

申请号：EP18721608.0

申请日：2018-04-12

申请人： Agenus Inc.

发明人： XIAO, Yanping ,  WILSON, Nicholas Stuart ,  MORIN, Benjamin Maxime ,  FINDEIS, Mark Arthur ,  MUNDT, Cornelia Anne ,  VAN DIJK, Marc ,  CHAND, Dhan Sidhartha ,  SAVITSKY, David Adam ,  UNDERWOOD, Dennis John ,  IGNATOVICH, Olga

IPC分类号： C07K16/28