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公开(公告)号：EP3303394B1
公开(公告)日：2020-04-08
申请号：EP16728509.7
申请日：2016-05-27
申请人： Agenus Inc. , Ludwig Institute for Cancer Research Ltd , Memorial Sloan Kettering Cancer Center
发明人： van DIJK, Marc , MUNDT, Cornelia, Anne , RITTER, Gerd , SCHAER, David , WOLCHOK, Jedd, David , MERGHOUB, Taha , SAVITSKY, David, Adam , FINDEIS, Mark, Arthur , WILSON, Nicholas, Stuart
IPC分类号： C07K16/28
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公开(公告)号：EP3551225A1
公开(公告)日：2019-10-16
申请号：EP17818020.4
申请日：2017-12-07
申请人： Agenus Inc. , Ludwig Institute for Cancer Research Ltd , Memorial Sloan Kettering Cancer Center
发明人： VAN DIJK, Marc , MUNDT, Cornelia Anne , RITTER, Gerd , SCHAER, David , WOLCHOK, Jedd David , MERGHOUB, Taha , WILSON, Nicholas Stuart , SAVITSKY, David Adam , FINDEIS, Mark Arthur , ZAPPASODI, Roberta , HOLMGAARD, Rikke Bæk , CUILLEROT, Jean-Marie , PROSCURSHIM, Igor , SHEBANOVA, Olga
IPC分类号： A61K39/395 , C07K16/28
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公开(公告)号：EP3383431A1
公开(公告)日：2018-10-10
申请号：EP16871589.4
申请日：2016-12-02
申请人： Agenus Inc. , Memorial Sloan-Kettering Cancer Center , Ludwig Institute for Cancer Research Ltd
发明人： WILSON, Nicholas S. , WAIGHT, Jeremy D. , RITTER, Gerd , TSUJI, Takemasa , LEGER, Olivier , SEIBERT, Volker , SCHAER, David , MERGHOUB, Taha , UNDERWOOD, Dennis J. , GONZALEZ, Ana M. , VAN DIJK, Marc
IPC分类号： A61K39/395 , C07K16/28 , C07K16/30
CPC分类号： C07K16/2878 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/76
摘要： The present disclosure provides antibodies that specifically bind to human GITR, as well as compositions comprising such antibodies. In a specific aspect, the antibodies specifically bind to human GITR and deactivate, reduce, or inhibit GITR activity. The present disclosure also provides methods for treating autoimmune or inflammatory diseases disorders, by administering an antibody that specifically binds to human GITR and deactivates, reduces, or inhibits GITR activity.
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公开(公告)号：EP3383430A1
公开(公告)日：2018-10-10
申请号：EP16871583.7
申请日：2016-12-02
申请人： Agenus Inc. , Memorial Sloan-Kettering Cancer Center , Ludwig Institute for Cancer Research Ltd
发明人： WILSON, Nicholas S. , WAIGHT, Jeremy D. , RITTER, Gerd , SCHAER, David , HIRSCHHORN-CYMERMAN, Daniel , MERGHOUB, Taha , BREOUS-NYSTROM, Ekaterina V. , SEIBERT, Volker , TSUJI, Takemasa , LEGER, Olivier , UNDERWOOD, Dennis J. , VAN DIJK, Marc
IPC分类号： A61K39/395 , A61K47/68 , C07K16/28 , C07K16/30
CPC分类号： C07K16/2878 , A61K2039/505 , C07K16/2827 , C07K16/30 , C07K2317/30 , C07K2317/31 , C07K2317/732 , C07K2317/75 , C07K2317/76
摘要： The present disclosure provides multispecific (e.g., bispecific) antibodies that specifically bind to human GITR and/or human OX40 as well as compositions comprising such antibodies. In a specific aspect, the multispecific antibodies specifically bind to human GITR and OX40 and modulate GITR and/or OX40 activity, e.g., enhance, activate, or induce GITR and/or OX40 activity, or reduce, deactivate, or inhibit GITR and/or OX40 activity. The present disclosure also provides methods for treating disorders, such as cancer, by administering a multispecific antibody that specifically binds to human GITR and/or OX40 and modulates GITR and/or OX40 activity, e.g., enhances, activates, or induces GITR and/or OX40 activity. Also provided are methods for treating autoimmune or inflammatory diseases or disorders, by administering a multispecific antibody that specifically binds to human GITR and/or OX40 and modulates GITR and/or OX40 activity, e.g., reduces, deactivates, or inhibits GITR and/or OX40 activity.
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公开(公告)号：EP3292152A1
公开(公告)日：2018-03-14
申请号：EP16723616.5
申请日：2016-05-06
申请人： Agenus Inc. , Ludwig Institute for Cancer Research Ltd , Memorial Sloan Kettering Cancer Center
发明人： VAN DIJK, Marc , BREOUS-NYSTROM, Ekaterina , SEIBERT, Volker , RITTER, Gerd , SCHAER, David , HIRSCHHORN-CYMERMAN, Daniel , MERGHOUB, Taha , TANG, Hao , SAVITSKY, David A. , WAIGHT, Jeremy , WILSON, Nicholas S.
IPC分类号： C07K16/28
CPC分类号： C07K16/2878 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/2875 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/524 , C07K2317/56 , C07K2317/565 , C07K2317/70 , C07K2317/71 , C07K2317/74 , C07K2317/75 , C07K2317/92 , G01N33/6863 , G01N2333/70578
摘要： The present disclosure provides antibodies that specifically bind to human OX40 receptor (OX40) and compositions comprising such antibodies. In a specific aspect, the antibodies specifically bind to human OX40 and modulate OX40 activity, e.g., enhance, activate, or induce OX40 activity, or reduce, deactivate, or inhibit OX40 activity. The present disclosure also provides methods for treating disorders, such as cancer, by administering an antibody that specifically binds to human OX40 and modulates OX40 activity, e.g., enhances, activates, or induces OX40 activity. Also provided are methods for treating autoimmune or inflammatory diseases or disorders, by administering an antibody that specifically binds to human OX40 and modulates OX40 activity, e.g., reduces, deactivates, or inhibits OX40 activity.
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公开(公告)号：EP3736290A1
公开(公告)日：2020-11-11
申请号：EP20168222.6
申请日：2016-05-27
申请人： Agenus Inc. , Memorial Sloan-Kettering Cancer Center , Ludwig Institute for Cancer Research Ltd.
发明人： Van DIJK, Marc , MUNDT, Cornelia Anne , RITTER, Gerd , SCHAER, David , WOLCHOK, Jedd David , MERGHOUB, Taha , SAVITSKY, David Adam , FINDEIS, Mark Arthur , WILSON, Nicholas S
IPC分类号： C07K16/28
摘要： The instant disclosure provides antibodies that specifically bind to human CTLA-4 and antagonize CTLA-4 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
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公开(公告)号：EP3303394A1
公开(公告)日：2018-04-11
申请号：EP16728509.7
申请日：2016-05-27
申请人： Agenus Inc. , Ludwig Institute for Cancer Research Ltd , Memorial Sloan Kettering Cancer Center
发明人： van DIJK, Marc , MUNDT, Cornelia, Anne , RITTER, Gerd , SCHAER, David , WOLCHOK, Jedd, David , MERGHOUB, Taha , SAVITSKY, David, Adam , FINDEIS, Mark, Arthur , WILSON, Nicholas, Stuart
IPC分类号： C07K16/28
摘要： The instant disclosure provides antibodies that specifically bind to human CTLA-4 and antagonize CTLA-4 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
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公开(公告)号：EP4289484A3
公开(公告)日：2024-03-06
申请号：EP23190631.4
申请日：2017-12-07
申请人： Agenus Inc. , Ludwig Institute for Cancer Research Ltd. , Memorial Sloan-Kettering Cancer Center
发明人： VAN DIJK, Marc , MUNDT, Cornelia Anne , RITTER, Gerd , SCHAER, David , WOLCHOK, Jedd David , MERGHOUB, Taha , WILSON, Nicholas Stuart , SAVITSKY, David Adam , FINDEIS, Mark Arthur , UNDERWOOD, Dennis John , CUILLEROT, Jean-Marie , PROSCURSHIM, Igor , SHEBANOVA, Olga
摘要： The instant disclosure provides antibodies that specifically bind to CTLA-4 (e.g., human CTLA-4) and antagonize CTLA-4 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
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公开(公告)号：EP4289484A2
公开(公告)日：2023-12-13
申请号：EP23190631.4
申请日：2017-12-07
申请人： Agenus Inc. , Ludwig Institute for Cancer Research Ltd. , Memorial Sloan-Kettering Cancer Center
发明人： VAN DIJK, Marc , MUNDT, Cornelia Anne , RITTER, Gerd , SCHAER, David , WOLCHOK, Jedd David , MERGHOUB, Taha , WILSON, Nicholas Stuart , SAVITSKY, David Adam , FINDEIS, Mark Arthur , UNDERWOOD, Dennis John , CUILLEROT, Jean-Marie , PROSCURSHIM, Igor , SHEBANOVA, Olga
IPC分类号： A61P35/04
摘要： The instant disclosure provides antibodies that specifically bind to CTLA-4 (e.g., human CTLA-4) and antagonize CTLA-4 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
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公开(公告)号：EP3551660A1
公开(公告)日：2019-10-16
申请号：EP17818406.5
申请日：2017-12-07
申请人： Agenus Inc. , Ludwig Institute for Cancer Research Ltd , Memorial Sloan Kettering Cancer Center
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