发明公开
- 专利标题： NTCP INHIBITOR
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申请号： EP19738828.3申请日： 2019-01-11
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公开(公告)号： EP3738603A1公开(公告)日： 2020-11-18
- 发明人: SUGA, Hiroaki , PASSIOURA, Toby , WAKITA, Takaji , WATASHI, Koichi
- 申请人： The University of Tokyo , Japan as Represented by The Director-General of National Institute of Infectious Diseases
- 申请人地址： 3-1, Hongo 7-chome, Bunkyo-ku, Tokyo 113-8654 JP
- 专利权人： The University of Tokyo,Japan as Represented by The Director-General of National Institute of Infectious Diseases
- 当前专利权人： The University of Tokyo,Japan as Represented by The Director-General of National Institute of Infectious Diseases
- 当前专利权人地址： 3-1, Hongo 7-chome, Bunkyo-ku, Tokyo 113-8654 JP
- 代理机构： Mewburn Ellis LLP
- 优先权： JP2018002814 20180111
- 国际公布： WO2019139126 20190718
- 主分类号： A61K38/12
- IPC分类号： A61K38/12 ; A61P1/16 ; A61P31/12 ; A61P31/14 ; A61P31/20 ; A61P43/00 ; C07K5/04 ; C07K7/06 ; C07K7/08
摘要：
The present invention provides a sodium taurocholate cotransporting polypeptide (NTCP) inhibitor comprising a cyclic peptide having a Xw1-W-Xw2-W structure, wherein Xw1 and Xw2 are each independently T, S, I, L, or V, or a N-alkylamino acid thereof, or having a P-Xp1-Xp2-H structure, wherein Xp1 is any amino acid, and Xp2 is I, L, or V, or a N-alkylamino acid thereof, or a pharmaceutically acceptable salt thereof.
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