公开(公告)号：EP3738603A1

公开(公告)日：2020-11-18

申请号：EP19738828.3

申请日：2019-01-11

申请人： The University of Tokyo ,  Japan as Represented by The Director-General of National Institute of Infectious Diseases

发明人： SUGA, Hiroaki ,  PASSIOURA, Toby ,  WAKITA, Takaji ,  WATASHI, Koichi

IPC分类号： A61K38/12 ,  A61P1/16 ,  A61P31/12 ,  A61P31/14 ,  A61P31/20 ,  A61P43/00 ,  C07K5/04 ,  C07K7/06 ,  C07K7/08

摘要： The present invention provides a sodium taurocholate cotransporting polypeptide (NTCP) inhibitor comprising a cyclic peptide having a Xw1-W-Xw2-W structure, wherein Xw1 and Xw2 are each independently T, S, I, L, or V, or a N-alkylamino acid thereof, or having a P-Xp1-Xp2-H structure, wherein Xp1 is any amino acid, and Xp2 is I, L, or V, or a N-alkylamino acid thereof, or a pharmaceutically acceptable salt thereof.

公开(公告)号：EP4416282A1

公开(公告)日：2024-08-21

申请号：EP22879697.5

申请日：2022-10-14

申请人： The University of Queensland ,  The University of Tokyo

发明人： CRAIK, David James ,  DE VEER, Simon John ,  HUANG, Yen-Hua ,  SWEDBERG, Joakim Erik ,  SUGA, Hiroaki ,  LIU, Wenyu ,  PASSIOURA, Toby

IPC分类号： C12N15/10 ,  G01N33/68 ,  A61K38/00 ,  A61P29/00 ,  A61P7/02 ,  C07K14/415 ,  C40B30/04

CPC分类号： A61P7/02 ,  A61P29/00 ,  C07K14/415 ,  C40B30/04 ,  C12N15/1062 ,  A61K38/56