- 专利标题: DNA MOLECULE CODING FOR 5' UTR ENABLING HIGH RECOMBINANT PROTEIN EXPRESSION IN MONOCOTYLEDONS
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申请号: EP19785629.7申请日: 2019-04-09
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公开(公告)号: EP3778894A1公开(公告)日: 2021-02-17
- 发明人: KATO, Ko
- 申请人: National University corporation Nara Institute of Science and Technology
- 申请人地址: JP Ikoma-shi Nara 630-0192 8916-5, Takayama-cho
- 代理机构: Müller-Boré & Partner Patentanwälte PartG mbB
- 优先权: JP2018077249 20180413
- 国际公布: WO2019198724 20191017
- 主分类号: C12N15/113
- IPC分类号: C12N15/113 ; A01H1/00 ; A01H5/00 ; C12N5/10 ; C12N15/82 ; C12P21/02
摘要:
The purpose of the present invention is to provide technology for identifying a 5' UTR having excellent translation ability while taking into account 5' UTR variants in monocotyledons, providing a DNA molecule that codes for the 5' UTR, and efficiently producing a recombinant protein in the monocotyledons. It is possible to efficiently produce a recombinant protein in a monocotyledon by using a nucleic acid structure in a polynucleotide that codes for a foreign protein, said structure comprising a base sequence among the base sequences shown in sequences 1-4 and linking to a 5' UTR or a variant thereof.
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