A process for producing technetium-99m from a molybendum-100 metal powder, comprising the steps of: (i) irradiating in a substantially oxygen-free environment, a hardened sintered target plate coating with a Mo-100 metal, with protons produced by a cyclotron; (ii) dissolving molybdenum ions and technetium ions from the irradiated target plate with an H 2 O 2 solution to form an oxide solution; (iv) raising the pH of the oxide solution to about 14; (v) flowing the pH-adjusted oxide solution through a resin column to immobilize K[TcO 4 ] ions therefrom; (vi) eluting the bound K[TcO 4 ] ions from the resin column; (vii) flowing the eluted K[TcO 4 ] ions through an alumina column to immobilize K[TcO 4 ] ions thereon; (viii) washing the immobilized K[TcO 4 ] ions with water; (ix) eluting the immobilized K[TcO 4 ] ions with a saline solution; and (x) recovering the eluted Na[TcO 4 ] ions.