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1382 条记录 (耗时 0.018 秒)

    SYSTEM, APPARATUS AND METHOD FOR PRODUCING GALLIUM RADIOISOTOPES ON PARTICLE ACCELERATORS USING SOLID TARGETS AND GA-68 COMPOSITION PRODUCED BY SAME
    1.
    发明公开
    SYSTEM, APPARATUS AND METHOD FOR PRODUCING GALLIUM RADIOISOTOPES ON PARTICLE ACCELERATORS USING SOLID TARGETS AND GA-68 COMPOSITION PRODUCED BY SAME 审中-公开

    公开(公告)号：EP4389155A3

    公开(公告)日：2024-11-13

    申请号：EP24173891.3

    申请日：2018-07-30

    申请人： Triumf Inc.

    发明人： ZEISLER, Stefan ,  KUMLIN, Joel Oscar Olsson

    IPC分类号： G21G1/10 ,  H05H6/00 ,  A61K51/02

    摘要： The present invention is directed to a system, apparatus, and method for producing gallium radioisotopes on particle accelerators using solid targets and a Ga-68 composition produced by this method. The solid target assembly apparatus has a metal disc and a zinc portion on the top of the disc. The apparatus is made by preparing a quantity of zinc, depositing it onto a metal disc, melting the zinc, and allowing it to cool and solidify. The disc surface may be prepared before applying zinc to it in order to facilitate bonding between the substrate and the zinc. Ga-68 is produced by placing the apparatus in a cyclotron target irradiation station, irradiating it, separating it from the irradiated Zn, and collecting and storing the separated Ga-68. The Ga-68 composition has the following quotient of activity quantity ratios: Ga-67/Ga-68 less than 1, and Ga-67/Ga-68 less than 1.

    ANTI-PSMA ANTIBODIES, USES THEREOF AND CONJUGATES THEREOF
    4.
    发明公开
    ANTI-PSMA ANTIBODIES, USES THEREOF AND CONJUGATES THEREOF 审中-公开

    公开(公告)号：EP4403226A3

    公开(公告)日：2024-10-16

    申请号：EP24173428.4

    申请日：2017-08-18

    申请人： Abzena (UK) Limited

    发明人： HOLGATE, Robert George Edward ,  HEARN, Arron Robert

    IPC分类号： C07K16/30 ,  A61K47/68 ,  A61P35/00

    摘要： An antibody or antigen-binding portion thereof which binds to PSMA and comprises a heavy chain variable domain comprising the sequences: CDR1: EYTIH (SEQ ID NO: 33) CDR2: NINPNX 1 GGTTYNQKFED (SEQ ID NO: 34) CDR3: X 2-5 DY (SEQ ID NO: 35) wherein X 1 is N or Q, and X 2-5 is YWLF, GWTF or AWTM, and wherein if X 2-5 is GWTF or AWTM, the amino acid residue at position H94 in the heavy chain variable region, based on Kabat numbering, is G; and if X 2-5 is YWLF, the amino acid residue at position H94 in the heavy chain variable region, based on Kabat numbering, is A. The invention also provides compounds that include the antibody or antigen-binding portion thereof, such as conjugates, and their use in the treatment or diagnosis of diseases, in particular cancers, particularly prostate cancer.