发明公开
- 专利标题： BENZYLAMINO SUBSTITUTED PYRIDOPYRIMIDINONES AND DERIVATIVES AS SOS1 INHIBITORS
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申请号： EP23156525.0申请日： 2018-12-20
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公开(公告)号： EP4219493A1公开(公告)日： 2023-08-02
- 发明人: FRANK, Markus , GILLE, Annika , GOEPPER, Stefan , OSTERMEIER, Markus , SANTAGOSTINO, Marco , WIPPICH, Julian , BAUM, Anke , GMACHL, Michael , HOFMANN, Marco Hans , KOFINK, Christiane , RAMHARTER, Juergen , RUDOLPH, Dorothea Ingrid , SAVARESE, Fabio , STADTMUELLER, Heinz , WUNBERG, Tobias
- 申请人： Boehringer Ingelheim International GmbH
- 申请人地址： DE 55216 Ingelheim am Rhein Binger Strasse 173
- 代理机构： Simon, Elke Anna Maria
- 优先权： EP17209865 20171221
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; C07D453/02 ; C07D519/00 ; A61P35/00 ; A61K31/519
摘要：
The present invention encompasses compounds of formula (I)
wherein the groups R 1 to R 4 , A and p have the meanings given in the claims and specification, their use as inhibitors of SOS1, pharmaceutical compositions which contain compounds of this kind and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.
wherein the groups R 1 to R 4 , A and p have the meanings given in the claims and specification, their use as inhibitors of SOS1, pharmaceutical compositions which contain compounds of this kind and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.
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