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公开(公告)号：EP4171570A1
公开(公告)日：2023-05-03
申请号：EP21739026.9
申请日：2021-06-23
IPC分类号： A61K31/519 , A61P35/00
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公开(公告)号：EP3464267A1
公开(公告)日：2019-04-10
申请号：EP17725933.0
申请日：2017-05-19
发明人： ENGELHARDT, Harald , ARNHOF, Heribert , CAROTTA, Sebastian , HOFMANN, Marco Hans , KERENYI, Marc , SCHARN, Dirk
IPC分类号： C07D401/14 , C07D401/10 , C07D471/04 , A61K31/4375 , A61P35/00
摘要： The present invention encompasses compounds of formula (I) wherein the groups R2 to R5, A, X and q have the meanings given in the claims and specification, their use as inhibitors of CDK8/19, pharmaceutical compositions which contain compounds of this kind and their use as medicaments, especially as agents for treatment and/or prevention of oncological diseases.
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公开(公告)号：EP4319757A1
公开(公告)日：2024-02-14
申请号：EP22716974.5
申请日：2022-04-07
IPC分类号： A61K31/517 , A61K31/519 , A61P35/00
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公开(公告)号：EP4219493A1
公开(公告)日：2023-08-02
申请号：EP23156525.0
申请日：2018-12-20
发明人： FRANK, Markus , GILLE, Annika , GOEPPER, Stefan , OSTERMEIER, Markus , SANTAGOSTINO, Marco , WIPPICH, Julian , BAUM, Anke , GMACHL, Michael , HOFMANN, Marco Hans , KOFINK, Christiane , RAMHARTER, Juergen , RUDOLPH, Dorothea Ingrid , SAVARESE, Fabio , STADTMUELLER, Heinz , WUNBERG, Tobias
IPC分类号： C07D471/04 , C07D453/02 , C07D519/00 , A61P35/00 , A61K31/519
摘要： The present invention encompasses compounds of formula (I)
wherein the groups R 1 to R 4 , A and p have the meanings given in the claims and specification, their use as inhibitors of SOS1, pharmaceutical compositions which contain compounds of this kind and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.-
公开(公告)号：EP3986408A1
公开(公告)日：2022-04-27
申请号：EP20733946.6
申请日：2020-06-17
IPC分类号： A61K31/519 , A61K45/06 , A61P35/00
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公开(公告)号：EP3728254A1
公开(公告)日：2020-10-28
申请号：EP18830816.7
申请日：2018-12-20
发明人： RAMHARTER, Juergen , KOFINK, Christiane , STADTMUELLER, Heinz , WUNBERG, Tobias , HOFMANN, Marco Hans , BAUM, Anke , GMACHL, Michael , RUDOLPH, Dorothea Ingrid , SAVARESE, Fabio , OSTERMEIER, Markus , FRANK, Markus , GILLE, Annika , GOEPPER, Stefan , SANTAGOSTINO, Marco , WIPPICH, Julian
IPC分类号： C07D471/04 , C07D453/02 , C07D519/00 , A61P35/00 , A61K31/519
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公开(公告)号：EP3464267B1
公开(公告)日：2020-09-23
申请号：EP17725933.0
申请日：2017-05-19
发明人： ENGELHARDT, Harald , ARNHOF, Heribert , CAROTTA, Sebastian , HOFMANN, Marco Hans , KERENYI, Marc , SCHARN, Dirk
IPC分类号： C07D401/14 , C07D401/10 , C07D471/04 , A61K31/4375 , A61P35/00
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公开(公告)号：EP3630822A1
公开(公告)日：2020-04-08
申请号：EP18727819.7
申请日：2018-06-01
IPC分类号： C07K16/22 , C07K16/18 , A61K39/395 , C07K16/28 , A61K31/502 , A61P35/00 , C07K16/46
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