- 专利标题： UNNATURAL AMINO ACID, AND USE THEREOF, RECOMBINANT PROTEIN CONTAINING SAME, AND RECOMBINANT PROTEIN CONJUGATE
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申请号： EP21951293.6申请日： 2021-07-29
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公开(公告)号： EP4378926A1公开(公告)日： 2024-06-05
- 发明人: YANG, Jinwei , YE, Chenghao , XIA, Gang , HUO, Pengchao , DING, Wen , CHEN, Longfei , JIAO, Lin , HUANG, Hao , HENG, Xin , ZHU, Jingjing , YING, Yuebin , LIANG, Xuejun
- 申请人： Novocodex Biopharmaceuticals Co., Ltd.
- 申请人地址： CN Shaoxing, Zhejiang 312366 No.502, Fl.5, Buiding C, high-tech venture park 398 Mahuan Road, Yuecheng District
- 专利权人： Novocodex Biopharmaceuticals Co., Ltd.
- 当前专利权人： Novocodex Biopharmaceuticals Co., Ltd.
- 当前专利权人地址： CN Shaoxing, Zhejiang 312366 No.502, Fl.5, Buiding C, high-tech venture park 398 Mahuan Road, Yuecheng District
- 代理机构： dompatent von Kreisler Selting Werner - Partnerschaft von Patent- und Rechtsanwälten mbB
- 国际申请： CN2021109276 2021.07.29
- 国际公布： WO2023004686 2023.02.02
- 主分类号： C07C271/22
- IPC分类号： C07C271/22 ; C07C235/78 ; C07C237/12 ; C07C235/20 ; C07K14/61 ; A61K47/54 ; A61K47/60 ; A61K38/27 ; A61P5/06
摘要：
The invention provides an unnatural amino acid, which is a compound with a structure as shown in formula (I) or an enantiomer thereof. The invention further provides use of the unnatural amino acid. Furthermore, the invention further provides a recombinant protein containing the unnatural amino acid and a protein conjugate prepared from the recombinant protein. The unnatural amino acid provided by the invention is simple and convenient to prepare, safe in nature, not easy to be inactivated when being inserted into a protein, and has a high binding rate with a coupling moiety, and the obtained conjugate is higher in stability. The unnatural amino acid provided by the invention is applicable to numerous fields, especially in preparation of a recombinant protein or a recombinant protein conjugate,
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