发明专利
- 专利标题： Method for producing 3-acylamino-thiophene derivative
- 专利标题（中）： 3-氨基亚氨基衍生物的制备方法
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申请号： JP2002113303申请日： 2002-04-16
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公开(公告)号： JP2003306487A公开(公告)日： 2003-10-28
- 发明人: ENOMOTO MIKI , MIYAHARA TORU , KAI AKIYOSHI , SATO KENICHI
- 申请人： Mitsui Chemicals Inc , 三井化学株式会社
- 专利权人： Mitsui Chemicals Inc,三井化学株式会社
- 当前专利权人： Mitsui Chemicals Inc,三井化学株式会社
- 优先权： JP2002113303 2002-04-16
- 主分类号： C07D333/36
- IPC分类号： C07D333/36 ; C07D409/12 ; C07D411/12 ; C07D417/12
摘要：
PROBLEM TO BE SOLVED: To provide a method for the industrial production of a 3-acylamino- thiophene derivative from 2-carboxymethyl-3-amino-thienyl in high yield by 3 steps comprising amidation, demethylation and decarbonation.
SOLUTION: The improvement of the production method comprises the use of pyridine as the base to be used in the amidation reaction, the selection of a proper reaction solvent, the setting of the aging temperature in two steps, etc. The method is industrially advantageous because the 3 reaction stages can be carried out in the same reactor without separating the reaction product in each unit operation.
COPYRIGHT: (C)2004,JPO
SOLUTION: The improvement of the production method comprises the use of pyridine as the base to be used in the amidation reaction, the selection of a proper reaction solvent, the setting of the aging temperature in two steps, etc. The method is industrially advantageous because the 3 reaction stages can be carried out in the same reactor without separating the reaction product in each unit operation.
COPYRIGHT: (C)2004,JPO
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