Compounds of the general formula (I):
[Formula 1]

Wherein, X represents a bond or a phenyl group which may be substituted,; R ¹ is substituted by optionally 7-membered heterocycle from 5 may, optionally substituted 5 may be 7-membered heteroaryl ring, and substituted are selected from optionally fused bicyclic group; R ² is hydrogen, C _1-6 alkyl and - (CH ₂₎ are selected from _{p--C 3-7} cycloalkyl; or, X-is selected bond, neither m and n is zero, R ¹ and R ² form a six-membered heterocycle from 5 together with the nitrogen atom to which they are bound, 6-membered heterocyclic ring from the 5 from oxygen and nitrogen it may contain one additional heteroatom or may be substituted by C _1-4 alkyl; R ³ is _{-CO-NH- (CH 2) q} -R 4 group ; U is selected from methyl and halogen; W of which is selected from methyl and chlorine; each V and Y are independently selected from hydrogen, methyl and halogen; Z is from -O- and binding It is selected; independently m and n is selected from 0, 1 and 2, each of the carbon atoms of the carbon chain resulting is substituted by more than two groups selected from C _1-6 alkyl independently even if well, yd + n total is 4 from 0; p-is selected from 0 and 1; q-and s is selected from 0, 1 and 2; r is from 0, 1 and 2 It is selected; or a pharmaceutically acceptable salt or solvate thereof, and their use as pharmaceuticals, in particular p38 kinase inhibitors.