To provide excellent EP2 agonist to safety.
The general formula (I):

(As indicated in the formula, all symbols in the specification.)
In the compound represented, a salt thereof, N- oxide thereof, a solvate or a prodrug thereof has an EP2 agonistic activity and also high safety, pharmaceuticals, and especially associated with the EP2 receptor diseases, for example, immunological diseases, allergic diseases, neuronal cell death, dysmenorrhea, premature labor, abortion, baldness, eye diseases, erectile dysfunction, arthritis, lung injury, pulmonary fibrosis, emphysema, bronchitis, chronic obstructive respiratory vessel diseases, bone diseases, is useful as a therapeutic agent, such as cartilage damage.