Invention Grant
- Patent Title: Cyclic peptide binder against oncogenic K-Ras
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Application No.: US15068528Application Date: 2016-03-11
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Publication No.: US10017540B2Publication Date: 2018-07-10
- Inventor: Ryan K. Henning , Ashwin N. Ram , Samir Das , Arundhati Nag , James R. Heath
- Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
- Applicant Address: US CA Pasadena
- Assignee: California Institute of Technology
- Current Assignee: California Institute of Technology
- Current Assignee Address: US CA Pasadena
- Agency: Pabst Patent Group LLP
- Main IPC: A61K38/12
- IPC: A61K38/12 ; A61P35/00 ; C07K7/64 ; G01N33/574 ; C07K14/82 ; C07K7/06 ; A61K38/00
Abstract:
Cyclic peptides represented by (Formula 1) selectively bind the oncoprotein K-Ras G12D in vitro and in cellulo, where Z1 and Z2 are each L-propargylglycine (Pra), azidoornithine (OrnN3), or L-azidolysine (Az4), and V1-V2-V3-V4-V5 is an amino acid variable region having a sequence selected from the group consisting of SEQ ID NOs: 1-20.
Public/Granted literature
- US20160264627A1 CYCLIC PEPTIDE BINDER AGAINST ONCOGENIC K-RAS Public/Granted day:2016-09-15
Information query
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