公开(公告)号：US20160264627A1

公开(公告)日：2016-09-15

申请号：US15068528

申请日：2016-03-11

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Ryan K. Henning ,  Ashwin N. Ram ,  Samir Das ,  Arundhati Nag ,  James R. Heath

IPC: C07K7/64 ,  G01N33/68

CPC classification number: C07K7/64 ,  A61K38/00 ,  C07K7/06 ,  C07K14/82 ,  G01N33/5748 ,  G01N2333/82 ,  G01N2333/914 ,  G01N2500/04

Abstract: Cyclic peptides represented by (Formula 1) selectively bind the oncoprotein K-Ras G12D in vitro and in cellulo, where Z1 and Z2 are each L-propargylglycine (Pra), azidoornithine (OrnN3), or L-azidolysine (Az4), and V1-V2-V3-V4-V5 is an amino acid variable region having a sequence selected from the group consisting of SEQ ID NOs: 1-20.

Abstract translation: 其中Z1和Z2分别为L-炔丙基甘氨酸（Pra），叠氮鸟氨酸（OrnN3）或L-叠氮基赖氨酸（Az4）和V1-V2-V3-V4-V5（纤维素酶），在体外和纤维素中选择性结合癌蛋白K-Ras G12D 是具有选自SEQ ID NO：1-20的序列的氨基酸可变区。

公开(公告)号：US10913774B2

公开(公告)日：2021-02-09

申请号：US16031840

申请日：2018-07-10

Applicant: California Institute of Technology

Inventor： Ryan K. Henning ,  Ashwin N. Ram ,  Samir Das ,  Arundhati Nag ,  James R. Heath

IPC: A61K38/00 ,  C07K7/64 ,  G01N33/574 ,  C07K14/82 ,  C07K7/06

Abstract: Cyclic peptides represented by (Formula 1) selectively bind the oncoprotein K-Ras G12D in vitro and in cellulo, where Z1 and Z2 are each L-propargylglycine (Pm), azidoornithine (OrnN3), or L-azidolysine (Az4), and V1-V2-V3-V4-V5 is an amino acid variable region having a sequence selected from the group consisting of SEQ ID NOs: 1-20.

公开(公告)号：US20180319844A1

公开(公告)日：2018-11-08

申请号：US16031840

申请日：2018-07-10

Applicant: California Institute of Technology

Inventor： Ryan K. Henning ,  Ashwin N. Ram ,  Samir Das ,  Arundhati Nag ,  James R. Heath

IPC: C07K7/64 ,  C07K7/06 ,  C07K14/82 ,  G01N33/574

CPC classification number: C07K7/64 ,  A61K38/00 ,  C07K7/06 ,  C07K14/82 ,  G01N33/5748 ,  G01N2333/82 ,  G01N2333/914 ,  G01N2500/04

Abstract: Cyclic peptides represented by (Formula 1) selectively bind the oncoprotein K-Ras G12D in vitro and in cellulo, where Z1 and Z2 are each L-propargylglycine (Pm), azidoornithine (OrnN3), or L-azidolysine (Az4), and V1-V2-V3-V4-V5 is an amino acid variable region having a sequence selected from the group consisting of SEQ ID NOs: 1-20.

公开(公告)号：US10017540B2

公开(公告)日：2018-07-10

申请号：US15068528

申请日：2016-03-11

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Ryan K. Henning ,  Ashwin N. Ram ,  Samir Das ,  Arundhati Nag ,  James R. Heath

IPC: A61K38/12 ,  A61P35/00 ,  C07K7/64 ,  G01N33/574 ,  C07K14/82 ,  C07K7/06 ,  A61K38/00

CPC classification number: C07K7/64 ,  A61K38/00 ,  C07K7/06 ,  C07K14/82 ,  G01N33/5748 ,  G01N2333/82 ,  G01N2333/914 ,  G01N2500/04

Abstract: Cyclic peptides represented by (Formula 1) selectively bind the oncoprotein K-Ras G12D in vitro and in cellulo, where Z1 and Z2 are each L-propargylglycine (Pra), azidoornithine (OrnN3), or L-azidolysine (Az4), and V1-V2-V3-V4-V5 is an amino acid variable region having a sequence selected from the group consisting of SEQ ID NOs: 1-20.