-
公开(公告)号：US10913774B2
公开(公告)日：2021-02-09
申请号：US16031840
申请日：2018-07-10
Applicant: California Institute of Technology
Inventor： Ryan K. Henning , Ashwin N. Ram , Samir Das , Arundhati Nag , James R. Heath
IPC: A61K38/00 , C07K7/64 , G01N33/574 , C07K14/82 , C07K7/06
Abstract: Cyclic peptides represented by (Formula 1) selectively bind the oncoprotein K-Ras G12D in vitro and in cellulo, where Z1 and Z2 are each L-propargylglycine (Pm), azidoornithine (OrnN3), or L-azidolysine (Az4), and V1-V2-V3-V4-V5 is an amino acid variable region having a sequence selected from the group consisting of SEQ ID NOs: 1-20.
-
2.发明申请PHOSPHORYLATED AKT-SPECIFIC CAPTURE AGENTS, COMPOSITIONS, AND METHODS OF USING AND MAKING 审中-公开磷酸钾特异性捕获剂，组合物和使用和制备方法公开(公告)号：US20150219657A1
公开(公告)日：2015-08-06
申请号：US14485243
申请日：2014-09-12
Applicant: California Institute of Technology
Inventor： James R. Heath , Arundhati Nag , Samir Das , Joseph O. Varghese , Ryan K. Henning
IPC: G01N33/574 , G01N33/58 , C07K7/06
Abstract: The present application provides stable peptide-based Akt capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing Akt capture agents using iterative on-bead in situ click chemistry.
Abstract translation: 本申请提供了稳定的基于肽的Akt捕获剂以及用作检测和诊断试剂以及用于治疗疾病和病症的方法。 该应用进一步提供了使用迭代的珠粒原位点击化学制造Akt捕获剂的方法。
-
Patent Agency Ranking
3.发明申请公开(公告)号：US20230019342A1
公开(公告)日：2023-01-19
申请号：US17850743
申请日：2022-06-27
Applicant: California Institute of Technology
Inventor： James R. Heath , Arundhati Nag , Samir Das , Joseph O. Varghese , Ryan K. Henning
IPC: G01N33/574 , C07K7/06 , C07K7/08 , C12Q1/48 , G01N33/58
Abstract: The present application provides stable peptide-based Akt capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing Akt capture agents using iterative on-bead in situ click chemistry.
-
4.发明授权公开(公告)号：US11371994B2
公开(公告)日：2022-06-28
申请号：US14485243
申请日：2014-09-12
Applicant: California Institute of Technology
Inventor： James R. Heath , Arundhati Nag , Samir Das , Joseph O. Varghese , Ryan K. Henning
IPC: C07K7/06 , C12Q1/48 , G01N33/574 , C07K7/08 , G01N33/58
Abstract: The present application provides stable peptide-based Akt capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing Akt capture agents using iterative on-bead in situ click chemistry.
-
公开(公告)号：US20160264627A1
公开(公告)日：2016-09-15
申请号：US15068528
申请日：2016-03-11
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Ryan K. Henning , Ashwin N. Ram , Samir Das , Arundhati Nag , James R. Heath
CPC classification number: C07K7/64 , A61K38/00 , C07K7/06 , C07K14/82 , G01N33/5748 , G01N2333/82 , G01N2333/914 , G01N2500/04
Abstract: Cyclic peptides represented by (Formula 1) selectively bind the oncoprotein K-Ras G12D in vitro and in cellulo, where Z1 and Z2 are each L-propargylglycine (Pra), azidoornithine (OrnN3), or L-azidolysine (Az4), and V1-V2-V3-V4-V5 is an amino acid variable region having a sequence selected from the group consisting of SEQ ID NOs: 1-20.
Abstract translation: 其中Z1和Z2分别为L-炔丙基甘氨酸（Pra），叠氮鸟氨酸（OrnN3）或L-叠氮基赖氨酸（Az4）和V1-V2-V3-V4-V5（纤维素酶），在体外和纤维素中选择性结合癌蛋白K-Ras G12D 是具有选自SEQ ID NO：1-20的序列的氨基酸可变区。
-
公开(公告)号：US20180319844A1
公开(公告)日：2018-11-08
申请号：US16031840
申请日：2018-07-10
Applicant: California Institute of Technology
Inventor： Ryan K. Henning , Ashwin N. Ram , Samir Das , Arundhati Nag , James R. Heath
IPC: C07K7/64 , C07K7/06 , C07K14/82 , G01N33/574
CPC classification number: C07K7/64 , A61K38/00 , C07K7/06 , C07K14/82 , G01N33/5748 , G01N2333/82 , G01N2333/914 , G01N2500/04
Abstract: Cyclic peptides represented by (Formula 1) selectively bind the oncoprotein K-Ras G12D in vitro and in cellulo, where Z1 and Z2 are each L-propargylglycine (Pm), azidoornithine (OrnN3), or L-azidolysine (Az4), and V1-V2-V3-V4-V5 is an amino acid variable region having a sequence selected from the group consisting of SEQ ID NOs: 1-20.
-
公开(公告)号：US10017540B2
公开(公告)日：2018-07-10
申请号：US15068528
申请日：2016-03-11
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Ryan K. Henning , Ashwin N. Ram , Samir Das , Arundhati Nag , James R. Heath
CPC classification number: C07K7/64 , A61K38/00 , C07K7/06 , C07K14/82 , G01N33/5748 , G01N2333/82 , G01N2333/914 , G01N2500/04
Abstract: Cyclic peptides represented by (Formula 1) selectively bind the oncoprotein K-Ras G12D in vitro and in cellulo, where Z1 and Z2 are each L-propargylglycine (Pra), azidoornithine (OrnN3), or L-azidolysine (Az4), and V1-V2-V3-V4-V5 is an amino acid variable region having a sequence selected from the group consisting of SEQ ID NOs: 1-20.
-
-
-
-
-
-
Search Results
7
records
(took 0.039 seconds)
