Provided are systems and methods for location-aware security configuration of peripheral devices. In various implementations, a location-aware peripheral device comprises an interface and a configuration engine. The interface may communicatively couple the peripheral device to a computing system. The configuration engine may be configured to, upon powering on in the computing system, detect a characteristic of the computing system. In some implementations, the configuration engine may further select a trust level for the computing system. In some implementations, selecting a trust level may include using the detected characteristic to identify a profile stored on the peripheral device. The profile may describe a pre-determined computing system. The configuration engine may further be configured to program the peripheral device with a configuration that is associated with the selected trust level. The configuration may program a feature of the peripheral device.