Technologies for efficiently compressing data with run detection include a compute device. The compute device is to produce a hash as a function of a symbol at a present position and a predefined number of symbols after the present position in an input stream, determine whether the symbol at the present position is part of a run, obtain, from a hash table, a chain of pointers to previous positions in the input stream associated with the hash, determine, as a function of whether the symbol is part of a run and to identify a matched string, a number of strings referenced by the chain of pointers to compare to a string associated with the present position in the input stream, and output, in response to an identification of a matched string, a reference to the matched string in a set of compressed output data.