In at least one embodiment, a membrane filtration element is provided. The element may include at least one feed spacer including a first set of parallel strands extending in a first direction and including a plurality of first strands having a first thickness and a plurality of second strands having a second thickness that is smaller than the first thickness. A second set of parallel strands may extend in a second direction that is transverse to the first direction. The second set of parallel strands may include a plurality of third strands having a third thickness and a plurality of fourth strands having a fourth thickness that is smaller than the third thickness. In one embodiment, the first and second sets of strands include alternating thick and thin strands, which reduce pressure drop in membrane filtration systems.