Invention Grant
- Patent Title: Transgenic mice expressing Y114F mutant prohibitin
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Application No.: US15278820Application Date: 2016-09-28
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Publication No.: US10036742B2Publication Date: 2018-07-31
- Inventor: Sudharsana Rao Ande , Khanh Hoa Nguyen , Suresh Mishra
- Applicant: University of Manitoba
- Applicant Address: CA Winnipeg, Manitoba
- Assignee: University of Manitoba
- Current Assignee: University of Manitoba
- Current Assignee Address: CA Winnipeg, Manitoba
- Agency: Ade & Company Inc.
- Agent Michael R. Williams; Ryan W. Dupuis
- Main IPC: G01N33/50
- IPC: G01N33/50 ; A01K67/027 ; C07K14/47
Abstract:
The Mito-Ob obese mouse model overexpresses the mitochondrial protein prohibitin (PHB). Mito-Ob male mice develop insulin resistance in addition to obesity and they do not develop overt diabetes. It has been discovered that these mice also spontaneously develop nonalcoholic steatohepatitis (NASH) and hepatocarcinogenesis over time. Also described is a mutant Mito-Ob mouse that develops lymphadenopathy and histiocytosis.
Public/Granted literature
- US20170089888A1 USES OF MITO-OB TRANSGENIC MICE Public/Granted day:2017-03-30
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