公开(公告)号：US10036742B2

公开(公告)日：2018-07-31

申请号：US15278820

申请日：2016-09-28

Applicant: University of Manitoba

Inventor： Sudharsana Rao Ande ,  Khanh Hoa Nguyen ,  Suresh Mishra

IPC: G01N33/50 ,  A01K67/027 ,  C07K14/47

CPC classification number: G01N33/5088 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2217/052 ,  A01K2227/105 ,  A01K2267/0331 ,  C07K14/4702 ,  C12N2830/008 ,  G01N2500/00

Abstract: The Mito-Ob obese mouse model overexpresses the mitochondrial protein prohibitin (PHB). Mito-Ob male mice develop insulin resistance in addition to obesity and they do not develop overt diabetes. It has been discovered that these mice also spontaneously develop nonalcoholic steatohepatitis (NASH) and hepatocarcinogenesis over time. Also described is a mutant Mito-Ob mouse that develops lymphadenopathy and histiocytosis.

公开(公告)号：US20170089888A1

公开(公告)日：2017-03-30

申请号：US15278820

申请日：2016-09-28

Applicant: University of Manitoba

Inventor： Sudharsana Rao Ande ,  Khanh Hoa Nguyen ,  Suresh Mishra

IPC: G01N33/50 ,  A01K67/027

CPC classification number: G01N33/5088 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2217/052 ,  A01K2227/105 ,  A01K2267/0331 ,  C07K14/4702 ,  C12N2830/008 ,  G01N2500/00

Abstract: The Mito-Ob obese mouse model overexpresses the mitochondrial protein prohibitin (PHB). Mito-Ob male mice develop insulin resistance in addition to obesity and they do not develop overt diabetes. It has been discovered that these mice also spontaneously develop nonalcoholic steatohepatitis (NASH) and hepatocarcinogenesis over time. Also described is a mutant Mito-Ob mouse that develops lymphadenopathy and histiocytosis.

公开(公告)号：US20150026833A1

公开(公告)日：2015-01-22

申请号：US14328888

申请日：2014-07-11

Applicant: University of Manitoba

Inventor： Sudharsana R. Ande ,  Suresh Mishra

IPC: A01K67/027

CPC classification number: A01K67/0276 ,  A01K67/0275 ,  A01K2227/105 ,  A01K2267/0362 ,  C07K14/4703 ,  C12N2830/008

Abstract: An obese mouse model was developed by overexpressing the mitochondrial protein prohibitin (PHB) in white adipose tissue (WAT) specific manner driven by adipocyte protein 2 (aP2) promoter. These mice begin to develop obesity as a result of mitochondrial remodeling (upregulation of mitochondrial biogenesis and function) in WAT.

Abstract translation: 通过由脂肪细胞蛋白2（aP2）启动子驱动的白细胞白细胞（WAT）特异性方式过表达线粒体蛋白prohibitin（PHB）来开发肥胖小鼠模型。 这些小鼠由于线粒体重塑（线粒体生物发生和功能的上调）在WAT中开始发展为肥胖。

公开(公告)号：US09781909B2

公开(公告)日：2017-10-10

申请号：US14328888

申请日：2014-07-11

Applicant: University of Manitoba

Inventor： Sudharsana R. Ande ,  Suresh Mishra

IPC: A01K67/027 ,  C07K14/47

CPC classification number: A01K67/0276 ,  A01K67/0275 ,  A01K2227/105 ,  A01K2267/0362 ,  C07K14/4703 ,  C12N2830/008

Abstract: An obese mouse model was developed by overexpressing the mitochondrial protein prohibitin (PHB) in white adipose tissue (WAT) specific manner driven by adipocyte protein 2 (aP2) promoter. These mice begin to develop obesity as a result of mitochondrial remodeling (upregulation of mitochondrial biogenesis and function) in WAT.