Invention Grant
- Patent Title: Formation of chromanes based on intermolecular reaction of alkynes with dimethylfuran in the presence of gold(I) complexes
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Application No.: US15535477Application Date: 2015-12-09
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Publication No.: US10047065B2Publication Date: 2018-08-14
- Inventor: Ulla Letinois , Thomas Netscher
- Applicant: DSM IP ASSETS B.V.
- Applicant Address: NL Heerlen
- Assignee: DSM IP ASSETS B.V.
- Current Assignee: DSM IP ASSETS B.V.
- Current Assignee Address: NL Heerlen
- Agency: Nixon & Vanderhye P.C.
- Priority: EP14198491 20141217
- International Application: PCT/EP2015/079111 WO 20151209
- International Announcement: WO2016/096566 WO 20160623
- Main IPC: C07D311/04
- IPC: C07D311/04 ; C07C1/32 ; C07F7/08 ; C07C45/00 ; C07C37/14 ; C07C37/00
Abstract:
The present invention relates to a method of preparing chromanes from 2,5-dimethylfuran and substituted alkynes comprising an long chain unsaturated alkyl group as substituent in the alpha position of a substituted phenol followed by oxidation, reduction and acid ring closure. It is particularly advantageous to use 2,5-dimethylfuran as this offers an ecological beneficial synthesis of β-tocopherol.
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