公开(公告)号：US11512034B2

公开(公告)日：2022-11-29

申请号：US17303462

申请日：2021-05-28

申请人： McMaster University

发明人： Jakob Magolan ,  Nicholas Jentsch ,  Xiong Zhang ,  Mathew Piotrowski

IPC分类号： C07C37/14 ,  C07J7/00 ,  B01J21/04 ,  C07D209/08 ,  C07C41/26 ,  C07D307/80 ,  C07C201/12 ,  C07J1/00 ,  C07D311/30 ,  C07D311/32 ,  C07C253/30

摘要： The present application describes process for preparing an ortho-allylated hydroxy aryl compounds such as compounds of Formula (I) by reacting an allylic alcohol with a hydroxy aryl compound in the presence of aluminum compound selected from alumina and aluminum alkoxides and in a non-protic solvent wherein at least one carbon atom ortho to the hydroxy group in the hydroxy aryl compound is unsubstituted. The present application also includes compounds of Formula (I).

公开(公告)号：US20220144736A1

公开(公告)日：2022-05-12

申请号：US17432696

申请日：2020-02-03

申请人： CHIRACON GMBH

发明人： RALF ZUHSE ,  DMYTRO OSTROVSKYI

IPC分类号： C07C37/055 ,  C07C37/14

摘要： The invention relates to a method for the preparation of cannabidiol and an intermediate for the preparation of cannabidiol, wherein two intermediates are obtained, namely a silylated olivetol and a silylated olivetol (2) and brominated olivetol (4) which are stable, storable and which do not have undesirable properties or byproducts.

公开(公告)号：US20190225566A1

公开(公告)日：2019-07-25

申请号：US16330470

申请日：2017-08-09

申请人： SHOWA DENKO K.K.

发明人： Aoi HASEGAWA ,  Yoshitaka ISHIBASHI

IPC分类号： C07C39/06 ,  C07C37/14 ,  C07C39/16 ,  C07C39/225 ,  C08L65/02

摘要： Provided is a method with which it is possible to produce a polyalkenylphenol compound having a narrow molecular weight distribution and low viscosity at high purity and high yield. A poly 2-alkenyl aromatic ether compound having two or more phenol skeletons is subjected to Claisen rearrangement in the presence of a phenol or naphthol compound.

公开(公告)号：US10196334B2

公开(公告)日：2019-02-05

申请号：US15758010

申请日：2016-09-07

申请人： BASF SE

发明人： Kai-Uwe Schoening ,  Walid A. Al-Akhdar ,  Tiziano Nocentini ,  Gerard Vilain

IPC分类号： C07C37/14 ,  B01J31/00 ,  B01J31/22

摘要： The present invention relates to a process for the preparation of 2,6-di-tert-butyl phenol by reacting phenol with isobutylene in presence of an aluminum phenoxide catalyst, comprising i) preparing an aluminum phenoxide catalyst and phenol comprising mixture a) by mix-ing aluminum metal with phenol, and activating the catalyst by heating the mixture to a temperature of 100 to 180° C., and ii) carrying out a reaction b) by reacting mixture a) with an isobutylene comprising stream comprising 20 to 90% by weight of isobutylene and 10 to 80% by weight of 1-butene and/or 2-butene, which reaction is carried out under pressure and the maximum pressure is 5 to 20 bar.

公开(公告)号：US10081585B2

公开(公告)日：2018-09-25

申请号：US14897864

申请日：2014-02-21

申请人： DIC Corporation

发明人： Yutaka Satou ,  Ayumi Takahashi

IPC分类号： C07C39/14 ,  C07C37/14 ,  H01L23/29 ,  C08G61/02 ,  C08G8/02 ,  C08L61/16 ,  C08K3/04 ,  C08K7/18 ,  H05K1/03 ,  H05K1/09 ,  C08G59/62 ,  C08L63/00 ,  C08L91/06 ,  C07C37/00 ,  C08L65/00

CPC分类号： C07C39/14 ,  C07C37/14 ,  C08G8/02 ,  C08G59/621 ,  C08G61/02 ,  C08K3/04 ,  C08L61/16 ,  C08L63/00 ,  C08L65/00 ,  C08L91/06 ,  H01L23/293 ,  H01L23/295 ,  H01L2924/0002 ,  H05K1/0373 ,  H05K1/09 ,  H01L2924/00

摘要： There are provided a compound containing a phenolic hydroxyl group, which exhibits excellent heat resistance and excellent flame retardancy in terms of a cured product thereof, a phenolic resin including the same, a curable composition and a cured product thereof, a semiconductor sealing material, and a printed circuit board. The compound containing a phenolic hydroxyl group has a molecular structure represented by the following General Formula (I): wherein X is a structural site represented by the following Structural Formula (x1) or (x2); wherein, in Formula (x1) or (x2), k is an integer of 1 to 3, m is 1 or 2, Ar is a structural site represented by the following Structural Formula (Ar1), and in a case where when k or m is 2 or greater, a plurality of Ar's may be the same as or different from each other; wherein r is 1 or 2.

公开(公告)号：US10059683B2

公开(公告)日：2018-08-28

申请号：US15199528

申请日：2016-06-30

申请人： NORAMCO, INC.

发明人： Lukas Dialer ,  Denis Petrovic ,  Ulrich Weigl

IPC分类号： C07D311/80 ,  C07C37/14 ,  C07D205/04 ,  C07C37/11 ,  C07D311/78 ,  C07D311/04

CPC分类号： C07D311/78 ,  C07C37/11 ,  C07C37/14 ,  C07D205/04 ,  C07D311/04 ,  C07D311/80

摘要： The present disclosure relates to the preparation of a cannabidiol compound or a derivative thereof. The cannabidiol compound or derivatives thereof can be prepared by an acid-catalyzed reaction of a suitably selected and substituted di-halo-olivetol or derivative thereof with a suitably selected and substituted cyclic alkene to produce a dihalo-cannabidiol compound or derivative thereof. The dihalo-cannabidiol compound or derivative thereof can be produced in high yield, high stereospecificity, or both. It can then be converted under reducing conditions to a cannabidiol compound or derivatives thereof.

公开(公告)号：US20170349563A1

公开(公告)日：2017-12-07

申请号：US15535477

申请日：2015-12-09

申请人： DSM IP ASSETS B.V.

发明人： Ulla LETINOIS ,  Thomas NETSCHER

IPC分类号： C07D311/04 ,  C07C37/14 ,  C07C1/32 ,  C07C37/00 ,  C07F7/08 ,  C07C45/00

CPC分类号： C07D311/04 ,  C07C1/321 ,  C07C37/00 ,  C07C37/14 ,  C07C45/00 ,  C07F7/0805 ,  C07C39/19

摘要： The present invention relates to a method of preparing chromanes from 2,5-dimethylfuran and substituted alkynes comprising an long chain unsaturated alkyl group as substituent in the alpha position of a substituted phenol followed by oxidation, reduction and acid ring closure. It is particularly advantageous to use 2,5-dimethylfuran as this offers an ecological beneficial synthesis of β-tocopherol.

公开(公告)号：US20170305825A1

公开(公告)日：2017-10-26

申请号：US15516763

申请日：2015-10-12

申请人： LANXESS Deutschland GmbH

发明人： Uwe BOEGER ,  Lutz HEUER ,  Eberhard ZIRNGIEBL ,  Alexander HENSELER ,  Eszter FARKAS

IPC分类号： C07C37/84 ,  C07C39/06 ,  C07C37/14

CPC分类号： C07C37/84 ,  C07C37/14 ,  C07C37/74 ,  C07C39/06

摘要： The present invention relates to an improved method for producing 4-isopropyl-3-methylphenol (p-thymol) from distillation residues of thymol production.

公开(公告)号：US20160185812A1

公开(公告)日：2016-06-30

申请号：US14405092

申请日：2014-10-10

申请人： ZHEJIANG UNIVERSITY

发明人： Shengming MA ,  Xin HUANG ,  Chunling FU

IPC分类号： C07H15/18 ,  C07H15/10 ,  C07C29/46 ,  C07C2/86 ,  C07C303/40 ,  C07C231/12 ,  C07C269/06 ,  C07C67/30 ,  C07H1/00 ,  C07C37/14

CPC分类号： C07H15/18 ,  C07B2200/07 ,  C07C2/867 ,  C07C29/32 ,  C07C29/46 ,  C07C37/14 ,  C07C67/30 ,  C07C67/343 ,  C07C231/12 ,  C07C269/06 ,  C07C303/40 ,  C07C2527/122 ,  C07C2601/14 ,  C07H1/00 ,  C07H15/10 ,  C07H15/14 ,  C07C33/02 ,  C07C33/30 ,  C07C33/14 ,  C07C33/38 ,  C07C69/602 ,  C07C69/608 ,  C07C311/16 ,  C07C233/65 ,  C07C271/12 ,  C07C15/44

摘要： The present invention relates to a process for efficiently synthesizing highly optically active 1,3-disubstituted allenes, i.e., a one-step process for preparing highly optically active 1,3-disubstituted allenes by using a functionalized terminal alkyne, an aldehyde and a chiral α,α-diphenyl prolinol as reactants under the catalysis of a divalent copper salt. The operation of the process is simple, and the raw materials and reagents are readily available. The process has a broad-spectrum of substrates and a good compatibility for a wide variety of functional groups such as glycosidic units, primary alcohols, secondary alcohols, tertiary alcohols, amides, malonates, etc., and does not require the protection for the functional groups. The obtained axially chiral allene has a moderate to high yield and a good diastereoselectivity or enantioselectivity.

摘要翻译： 本发明涉及一种有效合成高度光学活性的1,3-二取代的全烯的方法，即通过使用官能化的末端炔，醛和手性制备高度光学活性的1,3-二取代的丙烯的一步法 α，α-二苯基脯氨酸醇作为二价铜盐催化下的反应物。 该方法的操作简单，原料和试剂容易获得。 该方法具有广谱的底物和各种功能基团如糖苷单元，伯醇，仲醇，叔醇，酰胺，丙二酸酯等的良好的相容性，并且不需要保护功能性 团体 获得的轴向手性烯烯具有中等至高产率和良好的非对映选择性或对映选择性。

公开(公告)号：US09150494B2

公开(公告)日：2015-10-06

申请号：US11271154

申请日：2005-11-11

申请人： Anna Lee Tonkovich ,  Steven T. Perry ,  Timothy J. LaPlante ,  Kai Tod Paul Jarosch ,  Thomas P. Hickey ,  Sean Patrick Fitzgerald ,  Dongming Qiu ,  Ravi Arora ,  Timothy J. Sullivan ,  Paul Neagle

发明人： Anna Lee Tonkovich ,  Steven T. Perry ,  Timothy J. LaPlante ,  Kai Tod Paul Jarosch ,  Thomas P. Hickey ,  Sean Patrick Fitzgerald ,  Dongming Qiu ,  Ravi Arora ,  Timothy J. Sullivan ,  Paul Neagle

IPC分类号： C07C2/56 ,  C07C209/68 ,  B01F5/04 ,  B01F13/00 ,  B01J19/00 ,  C07C2/66 ,  C07C2/70 ,  C07C37/14 ,  B01J29/40 ,  B01J37/02 ,  B01J38/10

CPC分类号： C07C209/68 ,  B01F5/0475 ,  B01F13/0059 ,  B01J19/0093 ,  B01J29/40 ,  B01J37/0225 ,  B01J38/10 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/00826 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00835 ,  B01J2219/00837 ,  B01J2219/00844 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00905 ,  C07C2/66 ,  C07C2/70 ,  C07C37/14 ,  C07C2529/40 ,  Y02P20/582 ,  Y02P20/584 ,  C07C15/073 ,  C07C211/46 ,  C07C211/47 ,  C07C211/50 ,  C07C211/51 ,  C07C39/06 ,  C07C39/07

摘要： The disclosed invention relates to a process, comprising: flowing a first reactant feed stream comprising a reactant substrate and a second reactant feed stream comprising an alkylating agent, an acylating agent or a mixture thereof, in a process microchannel in contact with each other to form a product comprising at least one alkylation product, at least one acylation product, or a mixture thereof; transferring heat from the process microchannel to a heat sink; and removing the product from the process microchannel.

摘要翻译： 所公开的发明涉及一种方法，其包括：将包含反应物底物的第一反应物进料流和包含烷基化试剂，酰化剂或其混合物的第二反应物进料流在彼此接触的工艺微通道中流动以形成 包含至少一种烷基化产物，至少一种酰化产物或其混合物的产品; 将热量从工艺微通道转移到散热器; 并从工艺微通道中除去产品。