Invention Grant
- Patent Title: High-affinity small molecule formylpeptide receptor ligands from screening of combinatorial mixture-based libraries
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Application No.: US15013102Application Date: 2016-02-02
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Publication No.: US10048272B2Publication Date: 2018-08-14
- Inventor: Bruce S. Edwards , Larry A. Sklar , Clemencia Pinilla , Richard A. Houghten , Jon R. Appel , Marc A. Giulianotti , Jose Medina-Franco
- Applicant: STC.UNM , TORREY PINES INSTITUTE FOR MOLECULAR STUDIES
- Applicant Address: US NM Albuquerque US FL Port St. Lucie
- Assignee: STC.UNM,Torrey Pines Institute for Molecular Studies
- Current Assignee: STC.UNM,Torrey Pines Institute for Molecular Studies
- Current Assignee Address: US NM Albuquerque US FL Port St. Lucie
- Agent Henry D. Coleman; R. Neil Sudol
- Main IPC: A61K31/497
- IPC: A61K31/497 ; A61K31/517 ; A61K31/17 ; G01N33/68 ; C07D403/14 ; A61K31/496 ; A61K45/06 ; C07C275/28 ; C40B30/02 ; G01N33/74 ; A61K38/00 ; C07D241/08 ; C07K1/04
Abstract:
The present invention provides novel methods and assays for high-throughput screening of combinatorial libraries to identify FPR1 and/or FPR2 ligands (e.g., agonists and/or antagonists), preferably FPR1 agonists and/or FPR2 antagonists, by positional scanning deconvolution.The invention also provides novel FPR1 and FPR2 ligands (e.g, agonists and antagonists), related pharmaceutical compositions and methods of treating FPR1 and FPR2-related disorders.
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