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1.发明申请HIGH-AFFINITY SMALL MOLECULE FORMYLPEPTIDE RECEPTOR LIGANDS FROM SCREENING OF COMBINATORIAL MIXTURE-BASED LIBRARIES 审中-公开从组合混合型图书馆筛选出的高亲和力小分子甲基化受体配体公开(公告)号：US20160320402A1
公开(公告)日：2016-11-03
申请号：US15013102
申请日：2016-02-02
Applicant: STC.UNM , TORREY PINES INSTITUTE FOR MOLECULAR STUDIES
Inventor： Bruce S. Edwards , Larry A. Sklar , Clemencia Pinilla , Richard A. Houghten , Jon R. Appel , Marc A. Giulianotti , Jose Medina-Franco
IPC: G01N33/68 , A61K31/17 , A61K31/496 , C40B30/02 , G01N33/74
CPC classification number: G01N33/6845 , A61K31/17 , A61K31/496 , A61K38/00 , A61K45/06 , B01J2219/00585 , C07C275/28 , C07D241/08 , C07D403/14 , C07K1/047 , C40B30/02 , G01N33/74 , G01N2333/726 , A61K2300/00
Abstract: The present invention provides novel methods and assays for high-throughput screening of combinatorial libraries to identify FPR1 and/or FPR2 ligands (e.g., agonists and/or antagonists), preferably FPR1 agonists and/or FPR2 antagonists, by positional scanning deconvolution.The invention also provides novel FPR1 and FPR2 ligands (e.g, agonists and antagonists), related pharmaceutical compositions and methods of treating FPR1 and FPR2-related disorders.
Abstract translation: 本发明还提供新的FPR1和FPR2配体（例如激动剂和拮抗剂），相关的药物组合物和治疗FPR1和FPR2相关疾病的方法。
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公开(公告)号：US10048272B2
公开(公告)日：2018-08-14
申请号：US15013102
申请日：2016-02-02
Applicant: STC.UNM , TORREY PINES INSTITUTE FOR MOLECULAR STUDIES
Inventor： Bruce S. Edwards , Larry A. Sklar , Clemencia Pinilla , Richard A. Houghten , Jon R. Appel , Marc A. Giulianotti , Jose Medina-Franco
IPC: A61K31/497 , A61K31/517 , A61K31/17 , G01N33/68 , C07D403/14 , A61K31/496 , A61K45/06 , C07C275/28 , C40B30/02 , G01N33/74 , A61K38/00 , C07D241/08 , C07K1/04
Abstract: The present invention provides novel methods and assays for high-throughput screening of combinatorial libraries to identify FPR1 and/or FPR2 ligands (e.g., agonists and/or antagonists), preferably FPR1 agonists and/or FPR2 antagonists, by positional scanning deconvolution.The invention also provides novel FPR1 and FPR2 ligands (e.g, agonists and antagonists), related pharmaceutical compositions and methods of treating FPR1 and FPR2-related disorders.
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Patent Agency Ranking
公开(公告)号：US11932628B2
公开(公告)日：2024-03-19
申请号：US17567201
申请日：2022-01-03
Inventor： Carrie Haskell-Luevano , Skye Ross Doering , Marcello A. Giulianotti , Clemencia Pinilla , Radleigh G. Santos , Richard A. Houghten
IPC: C07D403/14 , A61K9/20 , A61K9/48 , A61P3/04
CPC classification number: C07D403/14 , A61K9/2013 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/485 , A61K9/4858 , A61K9/4866 , A61P3/04
Abstract: The invention provides compounds having the general formula I:
and salts thereof, wherein the variables R1, R2, R3 and R4 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.-
4.发明授权High-affinity small molecule formylpeptide receptor ligands from screening of combinatorial mixture-based libraries 有权高亲和力小分子甲酰肽受体配体筛选组合基于混合物的文库公开(公告)号：US09310364B1
公开(公告)日：2016-04-12
申请号：US14174564
申请日：2014-02-06
Applicant: STC. UNM , TORREY PINES INSTITUTE FOR MOLECULAR STUDIES
Inventor： Bruce S. Edwards , Larry A. Sklar , Clemencia Pinilla , Richard A. Houghten , Jon R. Appel , Marc A. Giulianotti , Jose Medina-Franco
IPC: A61K38/00 , A61K31/17 , C07D241/08 , C40B30/02 , G01N33/566 , C07D403/14 , A61K31/496 , A61K45/06 , C07C275/28 , C07K1/04
CPC classification number: G01N33/6845 , A61K31/17 , A61K31/496 , A61K38/00 , A61K45/06 , B01J2219/00585 , C07C275/28 , C07D241/08 , C07D403/14 , C07K1/047 , C40B30/02 , G01N33/74 , G01N2333/726 , A61K2300/00
Abstract: The present invention provides novel methods and assays for high-throughput screening of combinatorial libraries to identify FPR1 and/or FPR2 ligands (e.g., agonists and/or antagonists), preferably FPR1 agonists and/or FPR2 antagonists, by positional scanning deconvolution.The invention also provides novel FPR1 and FPR2 ligands (e.g, agonists and antagonists), related pharmaceutical compositions and methods of treating FPR1 and FPR2-related disorders.
Abstract translation: 本发明提供了用于通过位置扫描反卷积来组合文库以鉴定FPR1和/或FPR2配体（例如激动剂和/或拮抗剂），优选FPR1激动剂和/或FPR2拮抗剂的高通量筛选的新方法和测定法。 本发明还提供新的FPR1和FPR2配体（例如激动剂和拮抗剂），相关的药物组合物和治疗FPR1和FPR2相关疾病的方法。
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公开(公告)号：US10899793B2
公开(公告)日：2021-01-26
申请号：US15605213
申请日：2017-05-25
Inventor： Carrie Haskell-Luevano , Skye Ross Doering , Jon R. Appel , Marc A. Giulianotti , Richard A. Houghten , Clemencia Pinilla , Radleigh G. Santos
IPC: C07K5/10 , A61K38/00 , A61K38/07 , C07K14/575
Abstract: Certain embodiments of the invention provide a compound of formula (I): R1—C(═O)—W—X—Y—Z—N(R2)2 (I) or a salt thereof, wherein R1, R2, W, X, Y and Z are as defined herein, as well as methods of use thereof.
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公开(公告)号：US20170342107A1
公开(公告)日：2017-11-30
申请号：US15605213
申请日：2017-05-25
Inventor： Carrie Haskell-Luevano , Skye Ross Doering , Jon R. Appel , Marc A. Giulianotti , Richard A. Houghten , Clemencia Pinilla , Radleigh G. Santos
CPC classification number: C07K5/1027 , A61K38/00
Abstract: Certain embodiments of the invention provide a compound of formula (I): R1—C(═O)—W—X—Y—Z—N(R2)2 (I) or a salt thereof, wherein R1, R2, W, X, Y and Z are as defined herein, as well as methods of use thereof.
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公开(公告)号：US20220213068A1
公开(公告)日：2022-07-07
申请号：US17567201
申请日：2022-01-03
Inventor： Carrie Haskell-Luevano , Skye Ross Doering , Marcello A. Giulianotti , Clemencia Pinilla , Radleigh G. Santos , Richard A. Houghten
IPC: C07D403/14 , A61P3/04 , A61K9/20 , A61K9/48
Abstract: The invention provides compounds having the general formula I: and salts thereof, wherein the variables R1, R2, R3 and R4 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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