Invention Grant
- Patent Title: Implantable bio-resorbable polymer charged with fragile macromolecules
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Application No.: US14003528Application Date: 2012-03-09
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Publication No.: US10064948B2Publication Date: 2018-09-04
- Inventor: Laurence Moine , Alexandre Laurent , Michel Wassef , Laurent Bedouet , Stephanie Louguet , Valentin Verret , Emeline Servais
- Applicant: Laurence Moine , Alexandre Laurent , Michel Wassef , Laurent Bedouet , Stephanie Louguet , Valentin Verret , Emeline Servais
- Applicant Address: FR Jouy en Josas FR Paris FR Paris FR Paris
- Assignee: Occlugel,Centre National de la Recherche Scientifique (CNRS),Assistance Publique Hopitaux de Paris,Universite Paris Diderot—Paris 7
- Current Assignee: Occlugel,Centre National de la Recherche Scientifique (CNRS),Assistance Publique Hopitaux de Paris,Universite Paris Diderot—Paris 7
- Current Assignee Address: FR Jouy en Josas FR Paris FR Paris FR Paris
- Agency: Banner & Witcoff, Ltd.
- Priority: EP11305253 20110309
- International Application: PCT/EP2012/054178 WO 20120309
- International Announcement: WO2012/120139 WO 20120913
- Main IPC: A61K47/34
- IPC: A61K47/34 ; A61K9/00 ; A61L27/16 ; A61L27/54 ; A61L27/58 ; C08F290/06 ; A61K9/16 ; A61K38/00
Abstract:
The present invention relates to a macromolecule-loaded bioresorbable crosslinked polymer wherein the polymer is obtainable from the polymerization of: (i) at least one monomer of formula (I) (CH2═CR1)CO—K wherein: —K represents O—Z or NH—Z, Z representing (CR2R3)m—CH3, (CH2—CH2—O)m—H, (CH2—CH2—O)m—CH3, (CH2)m—NR4R5 with m representing an integer from 1 to 30; —R1, R2, R3, R4 and R5 independently represent H or a C1-C6 alkyl; and (ii) at least one bio-resorbable block copolymer cross-linker, and wherein the macromolecule is chosen in the group consisting of proteins and nucleic acids.
Public/Granted literature
- US20130344160A1 IMPLANTABLE BIO-RESORBABLE POLYMER CHARGED WITH FRAGILE MACROMOLECULES Public/Granted day:2013-12-26
Information query
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