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    Implantable swellable bio-resorbable polymer
    1.
    发明授权
    Implantable swellable bio-resorbable polymer 有权
    可植入的可溶胀生物可吸收聚合物

    公开(公告)号：US09320806B2

    公开(公告)日：2016-04-26

    申请号：US14003514

    申请日：2012-03-09

    Applicant: Laurence Moine ,  Alexandre Laurent ,  Michel Wassef ,  Laurent Bedouet ,  Stephanie Louguet ,  Valentin Verret ,  Emeline Servais

    Inventor： Laurence Moine ,  Alexandre Laurent ,  Michel Wassef ,  Laurent Bedouet ,  Stephanie Louguet ,  Valentin Verret ,  Emeline Servais

    IPC: A61K47/48 ,  A61K47/34 ,  C08F220/18 ,  C08F222/10 ,  C08F224/00

    CPC classification number: A61K47/48176 ,  A61K47/34 ,  A61K47/58 ,  A61K47/59 ,  C08F220/18 ,  C08F222/1006 ,  C08F224/00 ,  Y10T428/2982

    Abstract: The present invention relates to a polymer obtained from the polymerization of: (i) at least one monomer of formula (I) (CH2═CR1)CO—K (1) wherein: —K represents O—Z or N H—Z, Z representing (CR2R3)m-CH3, (CH2—CH2—O)m-H, (CH2—CH2—O)m-CH3, (CH2)m-NR4R5 with m representing an integer from 1 to 30; —R1, R2, R3, R4 and R5 independently represent H or a C1-C6 alkyl; (ii) at least between 0.1 and 50% mol, advantageously between 1 and 30% mol, more advantageously between 1 and 20 mol % of a cyclic monomer having a exomethylene group of formula (II) wherein: — R6, R7, R8 and R9 represent independently H or a C5-C7 aryl group or R6 and R9 are absent and R7 and R8 form together with the carbon atom on which they are bonded a C5-C7 aryl group; —i and j represent independently an integer chosen between 0 and 2; —X represents either O or X is not present and in this latter case, CR6R7 and CR8R9 are linked via a single bond C—C and (iii) at least one bio-resorbable block copolymer cross-linker.

    Abstract translation: 本发明涉及聚合得到的聚合物：（i）至少一种式（I）单体（CH 2 = CR 1）CO-K（1）其中：-K表示O-Z或NH-Z，Z 代表（CR 2 R 3）m -CH 3，（CH 2 -CH 2 -O）m H，（CH 2 -CH 2 -O）m -CH 3，（CH 2）m -NR 4 R 5，m代表1至30的整数; -R1，R2，R3，R4和R5独立地表示H或C1-C6烷基; （ii）至少0.1至50摩尔％，有利地为1至30摩尔％，更有利地为1至20摩尔％的具有式（II）的外亚甲基的环状单体，其中：-R 6，R 7，R 8和 R9独立地表示H或C5-C7芳基或R6和R9不存在，R7和R8与它们所连接的碳原子一起形成C5-C7芳基; -i和j独立地表示选自0和2之间的整数; -X表示O或X不存在，并且在后一种情况下，CR 6 R 7和CR 8 R 9通过单键C-C和（iii）至少一种生物可吸收嵌段共聚物交联剂连接。

    METHOD FOR ESTIMATING THE COMPONENTS OF THE FORCE TORSOR THAT ARE APPLIED TO A BEARING
    5.
    发明申请
    METHOD FOR ESTIMATING THE COMPONENTS OF THE FORCE TORSOR THAT ARE APPLIED TO A BEARING 有权
    用于估计应用于轴承的强力部件的组件的方法

    公开(公告)号：US20090210172A1

    公开(公告)日：2009-08-20

    申请号：US12364538

    申请日：2009-02-03

    Applicant: Christophe Duret ,  David Kwapisz ,  Alexandre Laurent

    Inventor： Christophe Duret ,  David Kwapisz ,  Alexandre Laurent

    IPC: G06F19/00 ,  G01L1/00

    CPC classification number: G01M13/04 ,  G01L5/0019

    Abstract: A method is provided for estimating the components of the force torsor that are applied to a bearing, which method provides for the measurement of a vector (Vm) of N deformations and for the use of a physical model linking a vector (Q) of at most N representative values of the components of the torsor with a deformation measurement vector, the method comprises the following iterative steps: introduction of a vector (Q) of representative values into the model in order to calculate a deformation measurement vector (Vc); and carrying out a pertinence test (T) between the deformation measurement vector (Vc) which is calculated and the measured vector (Vm); if the test (T) is negative, establishing at least one new vector (Q) of representative values to be introduced into the model according to the result of the test; or if the test (T) is positive, storing the vector (Q) of introduced values; wherein the estimated components of the force torsor are established according to at least one stored vector (Q) of values.

    Abstract translation: 提供了一种用于估计应用于轴承的力扭杆的部件的方法，该方法提供了N个变形的矢量（Vm）的测量，并且使用连接矢量（Q）的物理模型 具有变形测量向量的躯体部件的最多N个代表值，该方法包括以下迭代步骤：将代表值的向量（Q）引入到模型中，以便计算变形测量向量（Vc）; 并进行计算出的变形测量​​矢量（Vc）和测量矢量（Vm）之间的相关性测试（T）。 如果测试（T）为负值，则根据测试结果建立至少要引入模型的代表值的新向量（Q）; 或者如果测试（T）为正，则存储引入值的向量（Q）; 其中根据至少一个存储的值的向量（Q）建立所述力扭力的估计分量。

    Hydrophilic polymer biomaterial having a specific magnetic resonance imaging signal and process for the preparation of said biomaterial
    6.
    发明授权
    Hydrophilic polymer biomaterial having a specific magnetic resonance imaging signal and process for the preparation of said biomaterial 有权
    具有特定磁共振成像信号的亲水性聚合物生物材料和用于制备所述生物材料的方法

    公开(公告)号：US07407646B2

    公开(公告)日：2008-08-05

    申请号：US10278256

    申请日：2002-10-23

    Applicant: Alexandre Laurent ,  Denis Labarre

    Inventor： Alexandre Laurent ,  Denis Labarre

    IPC: A61B5/055

    CPC classification number: C08K9/08

    Abstract: A charged biomaterial including at least one first hydrophilic polymer, and superparamagnetic iron oxide particles complexed with a second hydrophilic polymer substantially identical to or different from the first hydrophilic polymer, wherein the superparamagnetic iron oxide particles complexed with the second hydrophilic polymer are distributed substantially homogeneously and substantially without aggregates in the first hydrophilic polymer. A process for preparing a charged biomaterial including forming an aqueous solution of hydrophilic monomers and superparamagnetic iron oxide particles complexed with a hydrophilic polymer including monomers substantially identical to or different from the hydrophilic monomers, polymerizing the solution and forming a polymer hydrogel in which are distributed substantially homogeneously and substantially without aggregates the superparamagnetic iron oxide particles complexed with the hydrophilic polymer.

    Abstract translation: 包含与第一亲水性聚合物基本相同或不同的第二亲水性聚合物复合的至少一种第一亲水聚合物和超顺磁性氧化铁颗粒的带电生物材料，其中与第二亲水性聚合物复合的超顺磁性氧化铁颗粒基本均匀地分布， 基本上没有第一亲水性聚合物中的聚集体。 一种制备带电生物材料的方法，包括形成与亲水性聚合物复合的亲水性单体和超顺磁性氧化铁颗粒的水溶液，所述亲水性聚合物包括与亲水性单体基本上相同或不同的单体，使溶液聚合并形成聚合物水凝胶，其中基本上分布 均匀且基本上没有聚集与亲水性聚合物络合的超顺磁性氧化铁颗粒。

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