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    Implantable swellable bio-resorbable polymer
    2.
    发明授权
    Implantable swellable bio-resorbable polymer 有权
    可植入的可溶胀生物可吸收聚合物

    公开(公告)号：US09320806B2

    公开(公告)日：2016-04-26

    申请号：US14003514

    申请日：2012-03-09

    Applicant: Laurence Moine ,  Alexandre Laurent ,  Michel Wassef ,  Laurent Bedouet ,  Stephanie Louguet ,  Valentin Verret ,  Emeline Servais

    Inventor： Laurence Moine ,  Alexandre Laurent ,  Michel Wassef ,  Laurent Bedouet ,  Stephanie Louguet ,  Valentin Verret ,  Emeline Servais

    IPC: A61K47/48 ,  A61K47/34 ,  C08F220/18 ,  C08F222/10 ,  C08F224/00

    CPC classification number: A61K47/48176 ,  A61K47/34 ,  A61K47/58 ,  A61K47/59 ,  C08F220/18 ,  C08F222/1006 ,  C08F224/00 ,  Y10T428/2982

    Abstract: The present invention relates to a polymer obtained from the polymerization of: (i) at least one monomer of formula (I) (CH2═CR1)CO—K (1) wherein: —K represents O—Z or N H—Z, Z representing (CR2R3)m-CH3, (CH2—CH2—O)m-H, (CH2—CH2—O)m-CH3, (CH2)m-NR4R5 with m representing an integer from 1 to 30; —R1, R2, R3, R4 and R5 independently represent H or a C1-C6 alkyl; (ii) at least between 0.1 and 50% mol, advantageously between 1 and 30% mol, more advantageously between 1 and 20 mol % of a cyclic monomer having a exomethylene group of formula (II) wherein: — R6, R7, R8 and R9 represent independently H or a C5-C7 aryl group or R6 and R9 are absent and R7 and R8 form together with the carbon atom on which they are bonded a C5-C7 aryl group; —i and j represent independently an integer chosen between 0 and 2; —X represents either O or X is not present and in this latter case, CR6R7 and CR8R9 are linked via a single bond C—C and (iii) at least one bio-resorbable block copolymer cross-linker.

    Abstract translation: 本发明涉及聚合得到的聚合物：（i）至少一种式（I）单体（CH 2 = CR 1）CO-K（1）其中：-K表示O-Z或NH-Z，Z 代表（CR 2 R 3）m -CH 3，（CH 2 -CH 2 -O）m H，（CH 2 -CH 2 -O）m -CH 3，（CH 2）m -NR 4 R 5，m代表1至30的整数; -R1，R2，R3，R4和R5独立地表示H或C1-C6烷基; （ii）至少0.1至50摩尔％，有利地为1至30摩尔％，更有利地为1至20摩尔％的具有式（II）的外亚甲基的环状单体，其中：-R 6，R 7，R 8和 R9独立地表示H或C5-C7芳基或R6和R9不存在，R7和R8与它们所连接的碳原子一起形成C5-C7芳基; -i和j独立地表示选自0和2之间的整数; -X表示O或X不存在，并且在后一种情况下，CR 6 R 7和CR 8 R 9通过单键C-C和（iii）至少一种生物可吸收嵌段共聚物交联剂连接。

    IMPLANTABLE SWELLABLE BIO-RESORBABLE POLYMER
    4.
    发明申请
    IMPLANTABLE SWELLABLE BIO-RESORBABLE POLYMER 有权
    可植入式可剥离的生物可降解聚合物

    公开(公告)号：US20130344159A1

    公开(公告)日：2013-12-26

    申请号：US14003514

    申请日：2012-03-09

    Applicant: Laurence Moine ,  Alexandre Laurent ,  Michel Wassef ,  Laurent Bedouet ,  Stephanie Louguet ,  Valentin Verret ,  Emeline Servais

    Inventor： Laurence Moine ,  Alexandre Laurent ,  Michel Wassef ,  Laurent Bedouet ,  Stephanie Louguet ,  Valentin Verret ,  Emeline Servais

    IPC: A61K47/48 ,  A61K47/34

    CPC classification number: A61K47/48176 ,  A61K47/34 ,  A61K47/58 ,  A61K47/59 ,  C08F220/18 ,  C08F222/1006 ,  C08F224/00 ,  Y10T428/2982

    Abstract: The present invention relates to a polymer obtained from the polymerization of: (i) at least one monomer of formula (I) (CH2═CR1)CO—K (1) wherein: K represents O—Z or NH—Z, Z representing (CR2R3)m-CH3, (CH2—CH2—O)m-H, (CH2—CH2—O)m-CH3, (CH2)m-NR4R5 with m representing an integer from 1 to 30; R1, R2, R3, R4 and R5 independently represent H or a C1-C6 alkyl; (ii) at least between 0.1 and 50% mol, advantageously between 1 and 30% mol, more advantageously between 1 and 20 mol % of a cyclic monomer having a exomethylene group of formula (II) wherein: R6, R7, R8 and R9 represent independently H or a C5-C7 aryl group or R6 and R9 are absent and R7 and R8 form together with the carbon atom on which they are bonded a C5-C7 aryl group; i and j represent independently an integer chosen between 0 and 2; X represents either O or X is not present and in this latter case, CR6R7 and CR8R9 are linked via a single bond C—C and (iii) at least one bio-resorbable block copolymer cross-linker.

    Abstract translation: 本发明涉及由以下聚合得到的聚合物：（i）至少一种式（I）单体（CH2 = CR1）CO-K（1）其中：K代表OZ或NH-Z，Z代表（CR2R3） ）m-CH3，（CH2-CH2-O）mH，（CH2-CH2-O）m-CH3，（CH2）m-NR4R5，m代表1至30的整数; R1，R2，R3，R4和R5独立地表示H或C1-C6烷基; （ii）具有式（II）的外亚甲基的环状单体的至少0.1至50摩尔％，有利地为1至30摩尔％，更有利地为1至20摩尔％，其中：R6，R7，R8和R9 独立地表示H或C 5 -C 7芳基或R 6和R 9不存在，并且R 7和R 8与它们所连接的碳原子一起形成C 5 -C 7芳基; i和j独立地表示0和2之间的整数; X表示O或X不存在，在后一种情况下，CR6R7和CR8R9通过单键C-C和（iii）至少一种生物可吸收嵌段共聚物交联剂连接。

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