- 专利标题： Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxymorphone, prodrugs, methods of making and use thereof
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申请号： US15589158申请日： 2017-05-08
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公开(公告)号： US10071091B2公开(公告)日： 2018-09-11
- 发明人: Travis Mickle , Sven Guenther , Sanjib Bera , Jaroslaw Kanski , Andrea Martin
- 申请人： KemPharm, Inc.
- 申请人地址： US IA Coralville
- 专利权人： KemPharm, Inc.
- 当前专利权人： KemPharm, Inc.
- 当前专利权人地址： US IA Coralville
- 代理机构： McAndrews, Held & Malloy, Ltd.
- 代理商 Robert Hoag
- 主分类号： A61K31/44
- IPC分类号： A61K31/44 ; A61K31/485 ; A61K47/48 ; C07D489/08 ; C07D221/28
摘要：
The presently described technology provides compositions comprising aryl carboxylic acids and, for example NSAIDs, chemically conjugated to oxymorphone (4,5-α-epoxy-3,14-dihydroxy-17-methylmorphinan-6-one) to form novel prodrugs/compositions of oxymorphone, including benzoates, salicylates, propionates, fenamates, and acetates, which have a decreased potential for abuse of oxymorphone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.
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