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    COMPOSITIONS COMPRISING METHYLPHENIDATE-PRODRUGS, PROCESSES OF MAKING AND USING THE SAME
    4.
    发明申请
    COMPOSITIONS COMPRISING METHYLPHENIDATE-PRODRUGS, PROCESSES OF MAKING AND USING THE SAME 有权

    公开(公告)号：US20210130322A1

    公开(公告)日：2021-05-06

    申请号：US17115425

    申请日：2020-12-08

    申请人： KemPharm, Inc.

    发明人： Travis Mickle ,  Sven Guenther ,  Guochen Chi

    IPC分类号： C07D401/12 ,  A61K9/00 ,  C07D211/34 ,  A61K31/4545 ,  A61K47/54 ,  A61K31/4458

    摘要： The present technology is directed to compositions comprising d-threo-methylphenidate conjugates and/or unconjugated methylphenidate. The present technology also relates to compositions and oral formulations comprising d-threo-methylphenidate conjugated to nicotinoyl-L-serine, and/or a pharmaceutically acceptable salt thereof, and unconjugated methylphenidate and/or a pharmaceutically acceptable salt thereof. The present technology additionally relates to a pharmaceutical kit containing the composition comprising d-threo-methylphenidate conjugated to nicotinoyl-L-serine, and/or a pharmaceutically acceptable salt thereof, and unconjugated methylphenidate and/or a pharmaceutically acceptable salt thereof.

    Methylphenidate-prodrugs, processes of making and using the same
    6.
    发明授权
    Methylphenidate-prodrugs, processes of making and using the same 有权

    公开(公告)号：US10584112B2

    公开(公告)日：2020-03-10

    申请号：US16431275

    申请日：2019-06-04

    申请人： KemPharm, Inc.

    发明人： Travis Mickle ,  Sven Guenther ,  Guochen Chi

    IPC分类号： C07D401/12 ,  A61K9/00 ,  C07D211/34 ,  A61K31/4545

    摘要： The present technology is directed to compositions comprising d-threo-methylphenidate conjugates and unconjugated methylphenidate. The present technology also relates to compositions and oral formulations comprising d-threo-methylphenidate conjugated to nicotinoyl-L-serine, and/or a pharmaceutically acceptable salt thereof, and unconjugated methylphenidate and/or a pharmaceutically acceptable salt thereof. The present technology additionally relates to a pharmaceutical kit containing the composition comprising d-threo-methylphenidate conjugated to nicotinoyl-L-serine, and/or a pharmaceutically acceptable salt thereof, and unconjugated methylphenidate and/or a pharmaceutically acceptable salt thereof.

    COMPOSITIONS COMPRISING METHYLPHENIDATE-PRODRUGS, PROCESSES OF MAKING AND USING THE SAME
    7.
    发明申请
    COMPOSITIONS COMPRISING METHYLPHENIDATE-PRODRUGS, PROCESSES OF MAKING AND USING THE SAME 审中-公开

    公开(公告)号：US20200016272A1

    公开(公告)日：2020-01-16

    申请号：US16577876

    申请日：2019-09-20

    申请人： KemPharm, Inc.

    发明人： Travis Mickle ,  Sven Guenther ,  Guochen Chi

    IPC分类号： A61K47/54 ,  A61K9/00 ,  A61K31/4458

    摘要： The present technology is directed to d-threo-methylphenidate conjugates and a composition comprising d-threomethylphenidate conjugated to nicotinoyl-L-serine, or salt thereof. The present technology also relates to a composition comprising at least one conjugate of d-methylphenidate having at least two or more chiral centers. The composition is optically active. The present technology additionally relates to oral formulations and pharmaceutical kits comprising at least one d-threo-methylphenidate conjugate.The pharmaceutical kit may comprise a specified amount of individual doses in a package. Each individual dose in the package may contain a pharmaceutically effective amount of a conjugate of d-threo methylphenidate.