Invention Grant
- Patent Title: Optimized variants of anti-VEGF antibodies and methods of treatment thereof by reducing or inhibiting angiogenesis
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Application No.: US15274612Application Date: 2016-09-23
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Publication No.: US10072075B2Publication Date: 2018-09-11
- Inventor: Patrick Koenig , Chingwei Vivian Lee , Karthikan Rajagopal , Amin Famili , Germaine Fuh
- Applicant: Genentech, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Clark & Elbing LLP
- Agent Karen L. Elbing
- Main IPC: C07K16/22
- IPC: C07K16/22 ; A61K39/395 ; A61K47/34 ; C07K14/475 ; C07K16/44 ; C07K16/46 ; C12N15/10 ; C12N15/115 ; A61K47/60 ; A61K47/61 ; A61K39/00
Abstract:
The present invention provides anti-VEGF antibodies and compositions that include anti-VEGF antibodies (e.g., antibody conjugates, fusion proteins, and polymeric formulations), and uses thereof, for example for treatment of disorders associated with pathological angiogenesis. The present invention also provides methods of identifying antibody variants with improved properties, for example, enhanced binding affinity, stability, pharmacokinetics, and/or expression.
Public/Granted literature
- US20170096479A1 OPTIMIZED VARIANTS OF ANTI-VEGF ANTIBODIES Public/Granted day:2017-04-06
Information query
