- 专利标题: Transgenic transchromosomal rodents for making human antibodies
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申请号: US15218202申请日: 2016-07-25
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公开(公告)号: US10076103B2公开(公告)日: 2018-09-18
- 发明人: Kazuma Tomizuka , Isao Ishida , Nils Lonberg , Edward L. Halk
- 申请人: KYOWA HAKKO KIRIN CO., LTD. , E. R. SQUIBB & SONS, L.L.C.
- 申请人地址: JP Tokyo US NJ Princeton
- 专利权人: KYOWA HAKKO KIRIN CO., LTD.,E.R. SQUIBB & SONS, L.L.C.
- 当前专利权人: KYOWA HAKKO KIRIN CO., LTD.,E.R. SQUIBB & SONS, L.L.C.
- 当前专利权人地址: JP Tokyo US NJ Princeton
- 代理机构: Baker Botts L.L.P.
- 主分类号: C07H21/04
- IPC分类号: C07H21/04 ; A01K67/027 ; C07K14/735 ; C07K16/00 ; C07K16/18 ; C07K16/24 ; C07K16/28 ; C12N15/85 ; A01K67/02 ; C12N5/0781 ; C12N5/16 ; C12P21/00 ; C12Q1/6881 ; A61K39/00
摘要:
The present invention provides novel transgenic nonhuman mammals capable of producing human sequence antibodies, as well as methods of producing and using these antibodies.
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