Apparatus, systems and methods for error detection in transmissions on a multi-wire interface are disclosed. A method for transmitting data on the multi-wire interface includes transmitting data on a multi-wire interface includes obtaining a plurality of bits to be transmitted over a plurality of connectors, converting the plurality of bits into a sequence of symbols, and transmitting the sequence of symbols on the plurality of connectors. A predetermined number of least significant bits in the plurality of bits may be used for error detection. The predetermined number of least significant bits may have a constant value that is different from each of a plurality of error values. A symbol error affecting one or two symbols in the sequence of symbols may cause a decoded version of the predetermined number of least significant bits to have value that is one of a plurality of error values.