- Patent Title: Substituted benzofuran, benzothiophene and indole MCL-1 inhibitors
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Application No.: US14429799Application Date: 2013-09-20
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Publication No.: US10093640B2Publication Date: 2018-10-09
- Inventor: Taekyu Lee , Nicholas F. Pelz , Johannes Belmar , Zhiguo Bian , Edward T. Olejniczak , Stephen W. Fesik , Brian A. Chauder
- Applicant: VANDERBILT UNIVERSITY
- Applicant Address: US TN Nashville
- Assignee: Vanderbilt University
- Current Assignee: Vanderbilt University
- Current Assignee Address: US TN Nashville
- Agency: Michael Best & Friedrich LLP
- International Application: PCT/US2013/060881 WO 20130920
- International Announcement: WO2014/047427 WO 20140327
- Main IPC: C07D307/85
- IPC: C07D307/85 ; C07D405/10 ; C07D413/10 ; C07D401/10 ; A61K31/381 ; A61K31/343 ; A61K31/404 ; A61K31/4709 ; A61K31/422 ; A61K31/4439 ; A61K31/4155 ; A61K31/496 ; A61K31/5377 ; A61K45/06 ; C07D403/12 ; C07D401/14 ; C07D405/14 ; C07D333/70 ; C07D401/04 ; C07D401/06 ; C07D401/12 ; C07D403/04 ; C07D403/14 ; C07D405/04 ; C07D405/12 ; C07D409/04 ; C07D413/04 ; C07D413/12 ; C07D471/04 ; C07D209/42
Abstract:
The present invention provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present invention also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of Mcl-1 protein.
Public/Granted literature
- US20150336925A1 SUBSTITUTED BENZOFURAN, BENZOTHIOPHENE AND INDOLE MCL-1 INHIBITORS Public/Granted day:2015-11-26
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