Methods and apparatus to provision a workload in a virtual server rack deployment are disclosed. An example method includes determining, via a first resource manager executing on a processor, parameters of a request for allocating resources of a virtual server rack for performing a workload, determining logical computing resources to be utilized for performing the workload based on the parameters, determining first physical computing resources installed in a first physical rack and second physical computing resources installed in a second physical rack included in the virtual server rack to perform the determined logical computing resources, and instructing a first centralized manager of virtual hosts to provision the first physical computing resources into the logical computing resources to allocate the logical computing resources for performing the workload.