An image sensor device may include an array of image sensing pixels with adjacent image sensing pixels being arranged in macropixel, and a processor coupled to the array of image sensing pixels. The processor may be configured to receive pixel signals from the array of image sensing pixels, and arrange the received pixel signals into macropixel signal sets for respective macropixels. The processor may be configured to perform, in parallel, an image enhancement operation on the received pixel signals for each macropixel signal set to generate enhanced macropixel signals, and transmit the enhanced macropixel signals.