- 专利标题: Production of malonyl-CoA derived products via anaerobic pathways
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申请号: US13814616申请日: 2011-08-05
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公开(公告)号: US10138504B2公开(公告)日: 2018-11-27
- 发明人: William Ryan Sillers , Shital A. Tripathi , Arthur J. Shaw, IV , Aaron Argyros , David A. Hogsett
- 申请人: William Ryan Sillers , Shital A. Tripathi , Arthur J. Shaw, IV , Aaron Argyros , David A. Hogsett
- 申请人地址: HU Budapest
- 专利权人: Lallemand Hungary Liquidity Management LLC
- 当前专利权人: Lallemand Hungary Liquidity Management LLC
- 当前专利权人地址: HU Budapest
- 代理机构: Nutter McClennen & Fish LLP
- 国际申请: PCT/US2011/046869 WO 20110805
- 国际公布: WO2012/019175 WO 20120209
- 主分类号: C12P7/18
- IPC分类号: C12P7/18 ; C12N1/22 ; C12N9/88 ; C12N9/10 ; C12P7/64 ; C12P17/18
摘要:
The present invention provides for novel metabolic pathways to convert biomass and other carbohydrate sources to malonyl-CoA derived products, such as hydrocarbons and other bioproducts, under anaerobic conditions and with the net production of ATP. More specifically, the invention provides for a recombinant microorganism comprising one or more native and/or heterologous enzymes that function in one or more engineered metabolic pathways to achieve conversion of a carbohydrate source to, e.g., long-chain hydrocarbons and hydrocarbon derivatives, wherein the one or more native and/or heterologous enzymes is activated, upregulated, downregulated, or deleted. The invention also provides for processes to convert biomass to malonyl-CoA derived products which comprise contacting a carbohydrate source with a recombinant microorganism of the invention.