Disclosed is a lens-attached tissue cell pressurization device that is selectively coupled to an objective lens to perform pressurization in an optical device configured measure a cell tissue using the objective lens, the lens-attached tissue cell pressurization device including: a body extending in a lengthwise direction of the objective lens such that at least a portion of the objective lens is inserted into the body and having a connector selectively fixed to the objective lens; and an indenter provided at a lower end of the body, having a penetration part formed at a center of the indenter, and pressurizing the cell tissue by a change in a relative location of the objective lens and the cell tissue.