Techniques for automatically eradicating microorganisms (e.g., germs, bacteria, and/or viruses) from appliance handles using ultraviolet (UV) light are provided. In one aspect, a system for eradicating biological contaminants from a handle on an appliance door is provided. The system includes a UV light emitter for producing UV disinfecting light during a cleaning cycle; and a waveguide coating on the handle, coupled to the UV light emitter, for propagating the UV disinfecting light over a surface of the handle. The system can also include a control module for controlling the UV light emitter; and at least one sensor for providing data to the control module as to when to initiate or halt a cleaning cycle. A method for eradicating biological contaminants from a handle on an appliance door using the present system is also provided.